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Literature DB >> 487927

Association of cimetidine and bone-marrow suppression in man.

F Druart, C Frocrain, P Metois, J Martin, C Matuchansky.

Abstract

A 29-year old woman who was on steroids for Behcet's disease received intravenous cimetidine for severe gastrointestinal bleeding. A bone-marrow examination performed a few days prior to cimetidine treatment showed a normally active marrow. On the fifth day of cimetidine therapy, agranulocytosis (800/ml) and a very low platelet count (40,000/ml) were observed; bone-marrow failure was documented both by biopsy and aspiration. No other drug known to be myelotoxic was given. This severe hematologic side effect of cimetidine resolved within 10 days after discontinuation of the drug.

Entities: Chemical Disease Species

Mesh：

Substances：
Guanidines
Cimetidine

Year: 1979 PMID： 487927 DOI： 10.1007/bf01314472

Source DB: PubMed Journal: Dig Dis Sci ISSN： 0163-2116 Impact factor: 3.199

13 in total

1. Effects of metiamide on gastric acid hypersecretion, steatorrhea, and bone-marrow function in a patient with systemic mastocytosis.

Authors: E J Feldman; J I Isenberg
Journal: N Engl J Med Date: 1976-11-18 Impact factor: 91.245

2. Transient neutropenia in a patient receiving cimetidine.

Authors: M H Ufberg; C M Brooks; P R Bosanac; J E Kintzel
Journal: Gastroenterology Date: 1977-09 Impact factor: 22.682

3. Cimetidine and bone-marrow toxicity.

Authors: J W Byron
Journal: Lancet Date: 1977-09-10 Impact factor: 79.321

Review 4. Drug therapy: Cimetidine.

Authors: W Finkelstein; K J Isselbacher
Journal: N Engl J Med Date: 1978-11-02 Impact factor: 91.245

Association of cimetidine and bone-marrow suppression in man.

1. Effects of metiamide on gastric acid hypersecretion, steatorrhea, and bone-marrow function in a patient with systemic mastocytosis.

2. Transient neutropenia in a patient receiving cimetidine.

3. Cimetidine and bone-marrow toxicity.

Review 4. Drug therapy: Cimetidine.

Review 5. Oral ulceration and Behçet's syndrome.

6. Cimetidine therapy in a patient with metiamide-induced agranulocytosis.

7. Agranulocytosis four months after cimetidine therapy.

8. [Transient marrow aplasia during cimetidine treatment].

9. Cimetidine for gastric and duodenal ulcer?

10. Letter: Reversal of metiamide-induced agranulocytosis during treatment with cimetidine.

Review 1. Haematological adverse effects of histamine H2-receptor antagonists.

2. Cimetidine-induced bone marrow suppression.

3. Leucopenia and thrombocytopenia with cimetidine.

4. Cimetidine and hematologic suppression: things are not always as they appear.

5. Leukopenia with cimetidine.

6. Histopathology of the bone marrow in toxic myelopathy. A study of drug induced lesions in 57 patients.

7. Assessment of myelotoxicity caused by environmental chemicals.