Literature DB >> 487640

Immunological investigation in adenine phosphoribosyl transferase (APRT) deficiency.

W J Stevens, M E Peetermans, K J Van Acker.   

Abstract

In a family with partial or total adenine phosphoribosyl transferase (APRT) deficiency, T and B cell function was evaluated by counting rosette-forming cells, by investigating lymphocyte transformation to phytohaemagglutinin (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM), by assaying serum immunoglobulins and determining lymphocyte membrane immunoglobulins by immunofluorescence. Delayed cutaneous hypersensitivity was also assayed. The absence of gross immunological deficiency in the homozygotes, as well as in the heterozygotes, suggests that the APRT-mediated pathway of purine metabolism is relatively unimportant for lymphocyte function.

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Year:  1979        PMID： 487640      PMCID： PMC1537751     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  21 in total

1.  Selective severe cellular immunodeficiency. Effect of thymus transplantation and transfer factor administration.

Authors:  J W Stoop; V P Eijsvoogel; B J Zegers; B Blok-Schut; D W van Bekkum; R E Ballieux
Journal:  Clin Immunol Immunopathol       Date:  1976-11

Review 2.  Lymphocyte enzyme deficiencies and the metabolic basis of immunodeficiency disease.

Authors:  S H Polmar
Journal:  Clin Haematol       Date:  1977-06

3.  Adenine and adenosine metabolism in intact erythrocytes deficient in adenosine monophosphate-pyrophosphate phosphoribosyltransferase: a study of two families.

Authors:  B M Dean; D Perrett; H A Simmonds; A Sahota; K J Van Acker
Journal:  Clin Sci Mol Med       Date:  1978-10

4.  A role for purine metabolism in the immune response: Adenosine-deaminase activity and deoxyadenosine catabolism.

Authors:  H A Simmonds; G S Panayi; V Corrigall
Journal:  Lancet       Date:  1978-01-14       Impact factor: 79.321

5.  Abnormal purine metabolism and purine overproduction in a patient deficient in purine nucleoside phosphorylase.

Authors:  A Cohen; D Doyle; D W Martin; A J Ammann
Journal:  N Engl J Med       Date:  1976-12-23       Impact factor: 91.245

6.  Enzyme replacement therapy for adenosine deaminase deficiency and severe combined immunodeficiency.

Authors:  S H Polmar; R C Stern; A L Schwartz; E M Wetzler; P A Chase; R Hirschhorn
Journal:  N Engl J Med       Date:  1976-12-09       Impact factor: 91.245

Review 7.  The role of de novo purine synthesis in lymphocyte transformation.

Authors:  A C Allison; T Hovi; R W Watts; A D Webster
Journal:  Ciba Found Symp       Date:  1977

8.  Purine nucleoside phosphorylase deficiency associated with selective cellular immunodeficiency.

Authors:  J W Stoop; B J Zegers; G F Hendrickx; L H van Heukelom; G E Staal; P K de Bree; S K Wadman; R E Ballieux
Journal:  N Engl J Med       Date:  1977-03-24       Impact factor: 91.245

9.  Impaired defense against vaccinia in a child with T-lymphocyte deficiency associated with inosine phosphorylase defect.

Authors:  J L Virelizier; M Hamet; J J Ballet; P Reinert; C Griscelli
Journal:  J Pediatr       Date:  1978-03       Impact factor: 4.406

10.  A new form of nucleoside phosphorylase deficiency in two brothers with defective T-cell function.

Authors:  W D Biggar; E R Giblett; R L Ozere; B D Grover
Journal:  J Pediatr       Date:  1978-03       Impact factor: 4.406
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  1 in total

1.  Haemorrhagic shock and encephalopathy.

Authors:  K J Van Acker; A M Roodhooft; H Van Bever
Journal:  Eur J Pediatr       Date:  1986-04       Impact factor: 3.183
  1 in total

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