Literature DB >> 4874578

Lysergic acid diethylamide: sensitive neuronal units in the midbrain raphe.

G K Aghajanian, W E Foote, M H Sheard.   

Abstract

Units in areas of the midbrain rich in neurons containing serotonin respond to parenteral injections of d-lysergic acid diethylamide by a reversible cessation of spontaneous activity. The dose required is at or below threshold for gross behavioral effects. An inhibition of neurons containing serotonin after administration of d-lysergic acid diethylamide could account for the decreased metabolism of serotonin produced by this drug.

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Year:  1968        PMID： 4874578     DOI： 10.1126/science.161.3842.706

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  39 in total

1.  Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.

Authors:  J Scott Templin; Sun Jung Bang; Mariano Soiza-Reilly; Charles B Berde; Kathryn G Commons
Journal:  Brain Res       Date:  2012-04-04       Impact factor: 3.252

Review 2.  The behavioral pharmacology of hallucinogens.

Authors:  William E Fantegrossi; Kevin S Murnane; Chad J Reissig
Journal:  Biochem Pharmacol       Date:  2007-07-20       Impact factor: 5.858

Review 3.  Modulators in concert for cognition: modulator interactions in the prefrontal cortex.

Authors:  Lisa A Briand; Howard Gritton; William M Howe; Damon A Young; Martin Sarter
Journal:  Prog Neurobiol       Date:  2007-06-30       Impact factor: 11.685

4.  Responses of Midbrain raphe neurons to local temperature.

Authors:  T Hori; Y Harada
Journal:  Pflugers Arch       Date:  1976-07-30       Impact factor: 3.657

5.  Effect of lisuride and LSD on monoamine synthesis after axotomy or reserpine treatment in rat brain.

Authors:  W Kehr; W Speckenbach
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978 Jan-Feb       Impact factor: 3.000

Review 6.  Serotonin neuron diversity in the dorsal raphe.

Authors:  Rodrigo Andrade; Samir Haj-Dahmane
Journal:  ACS Chem Neurosci       Date:  2013-01-16       Impact factor: 4.418

7.  Do serotonin-containing dorsal raphe neurons possess autoreceptors?

Authors:  M E Trulson; T Crisp
Journal:  Exp Brain Res       Date:  1986       Impact factor: 1.972

8.  Behavioral and electrophysiological evidence of pain inhibition from midbrain stimulation in the cat.

Authors:  J L Oliveras; J M Besson; G Guilbaud; J C Liebeskind
Journal:  Exp Brain Res       Date:  1974-04-30       Impact factor: 1.972

Review 9.  5-HT1A Receptor-Mediated Autoinhibition and the Control of Serotonergic Cell Firing.

Authors:  Rodrigo Andrade; Daniel Huereca; Joseph G Lyons; Elaine M Andrade; Kelly M McGregor
Journal:  ACS Chem Neurosci       Date:  2015-05-26       Impact factor: 4.418

10.  Raphe - cerebellum interactions. I. Effects of cerebellar stimulation and harmaline administration on single unit activity of midbrain raphe neurons in the rat.

Authors:  M Weiss; J Pellet
Journal:  Exp Brain Res       Date:  1982       Impact factor: 1.972
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