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Literature DB >> 4873839

The effect of heterologous anti-lymphocytic serum on the small lymphocyte population of rats.

Abstract

Treatment of Lewis strain rats with a single subcutaneous dose of rabbit anti-rat thymocyte serum (RARTS) resulted in a marked depletion of small lymphocytes in the blood and thoracic duct lymph for approximately 10 days. While the thoracic duct lymphocytes were declining in numbers, rabbit antibody could be detected on the surfaces of a high percentage of the lymph cells. Furthermore, the thoracic duct lymphocytes were unable to initiate graft vs. host reactions during the period of depletion, even when injected in extremely large doses. Approximately 2 wk after treatment, the numbers and immune competence of the small lymphocytes returned to normal.

Entities: Species

Mesh：

Substances：
Antibodies
Immune Sera

Year: 1968 PMID： 4873839 PMCID： PMC2138510 DOI： 10.1084/jem.128.1.111

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

14 in total

1. The fate of parental strain small lymphocytes in F1 hybrid rats.

Authors: J L GOWANS
Journal: Ann N Y Acad Sci Date: 1962-10-24 Impact factor: 5.691

2. Quantitative studies on the induction of tolerance of skin homografts and on runt disease in neonatal rats.

Authors: R E BILLINGHAM; W K SILVERS; D STEINMULLER
Journal: J Natl Cancer Inst Date: 1962-02 Impact factor: 13.506

3. Effect of antilymphocytic antibody and antibody fragments on skin-homograft survival and the blood-lymphocyte count in rats.

Authors: N F Anderson; K James; M F Woodruff
Journal: Lancet Date: 1967-05-27 Impact factor: 79.321

4. Some effects of purified heterologous antihuman lymphocyte serum in man.

Authors: A P Monaco; M L Wood; P S Russell
Journal: Transplantation Date: 1967-07 Impact factor: 4.939

5. Further experiments on the action of antilymphocytic antiserum.

Authors: R H Levey; P B Medawar
Journal: Proc Natl Acad Sci U S A Date: 1967-08 Impact factor: 11.205

6. The relationship of lymphopenia production and lymphocyte agglutinating and cytotoxic antibody titers to the immunosuppressive potency of heterologous antilymphocyte plasma.

Authors: H F Jeejeebhoy
Journal: Transplantation Date: 1967-07 Impact factor: 4.939

Review 1. The selective action of antilymphocyte serum on recirculating lymphocytes: a review of the evidence and alternatives.

Authors: E M Lance
Journal: Clin Exp Immunol Date: 1970-06 Impact factor: 4.330

The effect of heterologous anti-lymphocytic serum on the small lymphocyte population of rats.

1. The fate of parental strain small lymphocytes in F1 hybrid rats.

2. Quantitative studies on the induction of tolerance of skin homografts and on runt disease in neonatal rats.

3. Effect of antilymphocytic antibody and antibody fragments on skin-homograft survival and the blood-lymphocyte count in rats.

4. Some effects of purified heterologous antihuman lymphocyte serum in man.

5. Further experiments on the action of antilymphocytic antiserum.

6. The relationship of lymphopenia production and lymphocyte agglutinating and cytotoxic antibody titers to the immunosuppressive potency of heterologous antilymphocyte plasma.

7. Studies on heterologous anti-lymphocyte serum in mice. I. In vitro and in vivo properties.

8. Nature and mode of action of antilymphocytic antiserum.

9. Studies on heterologous anti-lymphocyte serum in mice. II. Effect on the immune response.

10. The use of specific "lymphocyte" antisera to inhibit hypersensitive reactions of the "delayed" type.

Review 1. The selective action of antilymphocyte serum on recirculating lymphocytes: a review of the evidence and alternatives.

2. Anti-thymocyte serum effects on Plasmodium berghei infection in rats.

3. Effects of heterologous antineutrophil serum in guinea pigs. Hematologic and ultrastructural observations.

4. Suppressor activity of blood lymphocytes from guinea-pigs treated with ALS.

5. Studies on the immunotherapy of runt disease in rats.