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Literature DB >> 487233

Epidural analgesia and the metabolic response to surgery.

G M Cooper, A Holdcroft, G M Hall, J Alaghband-Zadeh.

Abstract

The effect of epidural blockade on the metabolic and hormonal responses to pelvic surgery was investigated in 14 female patients. Central venous blood samples were collected every 30 minutes and analysed for free fatty acids, glycerol, beta-hydroxybutyrate, acetoacetate, glucose, lactate, pyruvate, cortisol and growth hormone concentrations. There was no change in fat and glucose metabolism except for a transient decrease in lipolysis after 30 minutes of surgery. Cortisol and growth hormone values were significantly increased (p less than 0.01) after 60 minutes. A small but statistically significant increase in blood lactate concentration was observed (p less than 0.01) and the concept of a "metabolic V/Q" abnormality is postulated to explain the lacticacidaemia.

Entities: Chemical Disease Gene Species

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Year: 1979 PMID： 487233 DOI： 10.1007/bf03006452

Source DB: PubMed Journal: Can Anaesth Soc J ISSN： 0008-2856

13 in total

6. Neutrophils from patients undergoing hip surgery exhibit enhanced movement under spinal anaesthesia compared with general anaesthesia.

Authors: R Erskine; P K Janicki; P Ellis; M F James
Journal: Can J Anaesth Date: 1992-11 Impact factor: 5.063

6 in total

Epidural analgesia and the metabolic response to surgery.

1. Area of differential block in spinal anesthesia with hyperbaric tetracaine.

Review 2. Carbohydrate metabolism in vivo: regulation of the blood glucose level.

3. The blocking effect of epidural analgesia on the adrenocortical and hyperglycemic responses to surgery.

4. The effects of epidural anaesthesia on the pituitary-adrenal response to surgery.

5. Blood flow distribution in the human leg following epidural sympathetic blockade.

6. Circulatory effects of peridural block. I. Effects of level of analgesia and dose of lidocaine.

7. Substrate mobilisation during surgery. A comparison between halothane and fentanyl anaesthesia.

8. The assessment of the amount of fat in the human body from measurements of skinfold thickness.

9. Effect of epidural analgesia on the glycoregulatory endocrine response to surgery.

10. Obstetrical analgesia assessed by free fatty acid mobilisation.

1. Effect of lumbar epidural anaesthesia on plasma cortisol levels in children.

2. The anaesthetic modification of the endocrine and metabolic response to surgery.

Review 3. Anaesthetic risks in osteoarticular disorders.

4. [Post-aggression metabolism and peridural anesthesia: modification of catabolism by anesthesia procedures?].

5. Spinal anaesthesia but not general anaesthesia enhances neutrophil biocidal activity in hip arthroplasty patients.

6. Neutrophils from patients undergoing hip surgery exhibit enhanced movement under spinal anaesthesia compared with general anaesthesia.