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Literature DB >> 4868225

Autoimmune glomerulonephritis induced in sheep by injections of human lung and Freund's adjuvant.

Abstract

Sheep immunized with human lung and Freund's adjuvant develop progressive glomerulonephritis with deposition of autoantibodies and complement in the glomerular basement membrane. This nephritis appears to be the first autoimmune disease induced by antigens that are not organspecific. By clinical and immunopathologic criteria, this nephritis appears identical to the nephritis induced in sheep by human glomerular basement membrane and greatly resembles certain nephritides of man, in particular, the nephritis in Goodpasture's disease.

Entities: Disease Species

Mesh：

Substances：
Freund's Adjuvant

Year: 1968 PMID： 4868225 DOI： 10.1126/science.160.3824.204

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

11 in total

1. [Goodpasture's syndrome: progressive glomerulonephritis - disturbance of coagulation - ferritin-induced alveolar inhibition of fibrin polymerisation (author's transl)].

Authors: V Misgeld; H J Bungert; W Höfer
Journal: Klin Wochenschr Date: 1974-11-15

10. Experimental autoimmune glomerulonephritis induced by anti-glomerular basement membrane antibody. II. Effects of injecting heterologous, homologous, or autologous glomerular basement membranes and complete Freund's adjuvant into sheep.

Authors: R W Steblay; U H Rudofsky
Journal: Am J Pathol Date: 1983-11 Impact factor: 4.307

Autoimmune glomerulonephritis induced in sheep by injections of human lung and Freund's adjuvant.

1. [Goodpasture's syndrome: progressive glomerulonephritis - disturbance of coagulation - ferritin-induced alveolar inhibition of fibrin polymerisation (author's transl)].

2. Induction of progressive glomerulonephritis in rats by eluted -globulin.

3. Immunologic studies concerning the pulmonary lesions in Goodpasture's syndrome.

4. Goodpasture's syndrome. Treatment with nephrectomy and renal transplantation.

5. [Goodpasture syndrome and the effects of benzene].

6. [Goodpasture's syndrome: immunofluorescence studies of the lung (author's transl)].

7. Animal model of human disease: anti-glomerular-basement-membrane glomerulonephritis.

8. [Experimental demonstration of an identic antigenicity of the inner ear and kidney (author's transl)].

9. Characterization of human anti-glomerular basement membrane antibodies eluted from glomerulonephritic kidneys.

10. Experimental autoimmune glomerulonephritis induced by anti-glomerular basement membrane antibody. II. Effects of injecting heterologous, homologous, or autologous glomerular basement membranes and complete Freund's adjuvant into sheep.