Literature DB >> 4865906

Continuous production of Clostridium tetani toxin.

B Zacharias, M Björklund.   

Abstract

The continuous production of Clostridium tetani toxin has been carried out in a 1-liter stirred culture vessel for as long as 65 days. Toxin production of approximately 120 flocculating units per ml was maintained with a dilution rate of 0.125 hr(-1), a temperature of 34 C, a pH of 7.4, and the addition to the medium of 0.1 g of potassium chloride per liter. The average minimal lethal intraperitoneal dose of the toxin in mice was approximately 10(6) per ml.

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Year:  1968        PMID： 4865906      PMCID： PMC547313          DOI： 10.1128/am.16.1.69-72.1968

Source DB:  PubMed          Journal:  Appl Microbiol        ISSN： 0003-6919


  9 in total

1.  Simultaneous determination of dextran and glucose in serum.

Authors:  A REDEI; S NAGY
Journal:  Nature       Date:  1961-07-08       Impact factor: 49.962

2.  Rapid specific method for determination of aldosaccharides in body fluids.

Authors:  E HULTMAN
Journal:  Nature       Date:  1959-01-10       Impact factor: 49.962

3.  A semi-continuous method for the large-scale production of tetanus toxin.

Authors:  R O THOMSON
Journal:  Nature       Date:  1957-11-23       Impact factor: 49.962

4.  Variable factors influencing the production of tetanus toxin.

Authors:  J H MUELLER; P A MILLER
Journal:  J Bacteriol       Date:  1954-03       Impact factor: 3.490

5.  A simple method for obtaining highly potent tetanus toxin.

Authors:  W KOCH; D KAPLAN
Journal:  J Immunol       Date:  1953-01       Impact factor: 5.422

6.  Growth requirements of clostridium tetani: II. Factors exhausted by growth of the organism.

Authors:  R E Feeney; J H Mueller; P A Miller
Journal:  J Bacteriol       Date:  1943-12       Impact factor: 3.490

7.  Tetanus toxin production in the absence of protein.

Authors:  W C LATHAM; D F BENT; L LEVINE
Journal:  Appl Microbiol       Date:  1962-03

8.  [Not Available].

Authors:  M RAYNAUD
Journal:  Ann Inst Pasteur (Paris)       Date:  1951-04

9.  Large-scale production of tetanus toxoid.

Authors:  P A Nielsen
Journal:  Appl Microbiol       Date:  1967-03
  9 in total
  1 in total

Review 1.  Vaccine Production to Protect Animals Against Pathogenic Clostridia.

Authors:  Nicolas E Zaragoza; Camila A Orellana; Glenn A Moonen; George Moutafis; Esteban Marcellin
Journal:  Toxins (Basel)       Date:  2019-09-11       Impact factor: 4.546
  1 in total

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