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Literature DB >> 4863132

An assay method for leukocyte pyrogen.

Abstract

A method for assaying leukocyte pyrogen is described which is shown to remain valid despite the presence of very large amounts of bacterial endotoxin. It uses a combination of two procedures to inactivate endotoxin: incubation in normal rabbit plasma for 24 hr at 37 degrees C, and injection into rabbits rendered refractory to endotoxin. The validity of the assay was confirmed by formal statistical methods. A simplified assay method is also described which lacks full statistical validity, but is more suitable for routine use.

Entities: Species

Mesh：

Substances：
Endotoxins
Pyrogens

Year: 1967 PMID： 4863132 PMCID： PMC2138405 DOI： 10.1084/jem.126.5.745

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

8 in total

1. The initial process in the action of bacterial pyrogens in man.

Authors: J GERBRANDY; W I CRANSTON; E S SNELL
Journal: Clin Sci Date: 1954-11 Impact factor: 6.124

2. Studies on the pathogenesis of fever. II. Identification of an endogenous pyrogen in the blood stream following the injection of typhoid vaccine.

Authors: E ATKINS; W B WOOD
Journal: J Exp Med Date: 1955-11-01 Impact factor: 14.307

3. Inactivation of endotoxin by a humoral component. II. Interaction of endotoxin with serum and plasma.

Authors: R C SKARNES; F S ROSEN; M J SHEAR; M LANDY
Journal: J Exp Med Date: 1958-11-01 Impact factor: 14.307

4. Inactivation of endotoxin by a humoral component. III. Role of divalent cation and a dialyzable component.

Authors: F S ROSEN; R C SKARNES; M LANDY; M J SHEAR
Journal: J Exp Med Date: 1958-11-01 Impact factor: 14.307

5. Studies on the pathogenesis of fever. XI. Quantitative features of the febrile response to leucocytic pyrogen.

Authors: D L BORNSTEIN; C BREDENBERG; W B WOOD
Journal: J Exp Med Date: 1963-03-01 Impact factor: 14.307

6. Studies on the pathogenesis of fever. I. The presence of transferable pyrogen in the blood stream following the injection of typhoid vaccine.

Authors: E ATKINS; W B WOOD
Journal: J Exp Med Date: 1955-05-01 Impact factor: 14.307

7. Observations on the production of pyrogenic substances by rabbit and human leucocytes.

Authors: J H FESSLER; K E COOPER; W I CRANSTON; R L VOLLUM
Journal: J Exp Med Date: 1961-06-01 Impact factor: 14.307

8. Studies on the pathogenesis of fever. VI. The interaction of leucocytes and endotoxin in vitro.

Authors: R D COLLINS; W B WOOD
Journal: J Exp Med Date: 1959-12-01 Impact factor: 14.307

8 in total

6 in total

1. The effect of various amine-depleting drugs on the fever response exhibited by rabbits to bacterial or leucocyte pyrogen.

Authors: G Metcalf; J W Thompson
Journal: Br J Pharmacol Date: 1975-01 Impact factor: 8.739

An assay method for leukocyte pyrogen.

1. The initial process in the action of bacterial pyrogens in man.

2. Studies on the pathogenesis of fever. II. Identification of an endogenous pyrogen in the blood stream following the injection of typhoid vaccine.

3. Inactivation of endotoxin by a humoral component. II. Interaction of endotoxin with serum and plasma.

4. Inactivation of endotoxin by a humoral component. III. Role of divalent cation and a dialyzable component.

5. Studies on the pathogenesis of fever. XI. Quantitative features of the febrile response to leucocytic pyrogen.

6. Studies on the pathogenesis of fever. I. The presence of transferable pyrogen in the blood stream following the injection of typhoid vaccine.

7. Observations on the production of pyrogenic substances by rabbit and human leucocytes.

8. Studies on the pathogenesis of fever. VI. The interaction of leucocytes and endotoxin in vitro.

1. The effect of various amine-depleting drugs on the fever response exhibited by rabbits to bacterial or leucocyte pyrogen.

2. Observations on the mechanism of salicylate-induced antipyresis.

3. The effects of salicylate on temperature regulation in the rabbit.

4. Quantitative aspects of the release of leukocyte pyrogen from rabbit blood incubated with endotoxin.

5. Studies on the origin of human leukocytic pyrogen.

6. The rate of release of leukocyte pyrogen from rabbit blood incubated with endotoxin.