Literature DB >> 486272

Effect of nifedipine on atrioventricular conduction as compared with verapamil. Intracardiac electrophysiological study.

E Rowland, T Evans, D Krikler.   

Abstract

Intravenous nifedipine, a powerful calcium antagonist, had no obvious effect on atrioventricular conduction when administered to 11 patients during routine intracardiac electrophysiological studies. Verapamil on the other hand showed potent antiarrhythmic properties, depressing atrioventricular nodal conduction. Nifedipine thus appears safe in patients with angina pectoris who have disorders of atrioventricular nodal conduction, and in those receiving beta-adrenergic blocking drugs. There appear to be differential effects on the slow inward channels of cardiac cells with different 'calcium antagonists'.

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Year:  1979        PMID： 486272      PMCID： PMC482124          DOI： 10.1136/hrt.42.2.124

Source DB:  PubMed          Journal:  Br Heart J        ISSN： 0007-0769


  8 in total

1.  The effect of nifedipine on the sinus and atrioventricular node of the dog heart after beta-adrenergic receptor blockade.

Authors:  J P Amlie; K Landmark
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1978-04

2.  Verapamil in the treatment of paroxysmal supraventricular tachycardia.

Authors:  D M Krikler; R A Spurrell
Journal:  Postgrad Med J       Date:  1974-07       Impact factor: 2.401

3.  Effect of verapamil on the noraml action potential and on a calcium-dependent slow response of canine cardiac Purkinje fibers.

Authors:  P F Cranefield; R S Aronson; A L Wit
Journal:  Circ Res       Date:  1974-02       Impact factor: 17.367

4.  Effects of agents which inhibit the slow channel on sinus node automaticity and atrioventricular conduction in the dog.

Authors:  D P Zipes; J C Fischer
Journal:  Circ Res       Date:  1974-02       Impact factor: 17.367

5.  Effects of verapamil on sinus node function in man.

Authors:  G Breithardt; L Seipel; E Wiebringhaus; F Loogen
Journal:  Eur J Cardiol       Date:  1978-10

6.  Effects of nifedipine, a potent calcium-antagonistic coronary vasodilator, on atrioventricular conduction and blood flow in the isolated atrioventricular node preparation of the dog.

Authors:  N Taira; A Narimatsu
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1975       Impact factor: 3.000

7.  The relationship between posture, blood pressure and electrophysiological properties in patients with paroxysmal supraventricular tachycardia.

Authors:  P V Curry; E Rowland; K M Fox; D M Krikler
Journal:  Arch Mal Coeur Vaiss       Date:  1978-03

8.  Immediate effects of intravenous verapamil in cardiac arrhythmias.

Authors:  L Schamroth; D M Krikler; C Garrett
Journal:  Br Med J       Date:  1972-03-11
  8 in total
  25 in total

1.  The effects of verapamil on cerebrospinal fluid pressure in surgical patients.

Authors:  T Nishikawa; A Namiki
Journal:  J Anesth       Date:  1987-09-01       Impact factor: 2.078

2.  Trial of early nifedipine in acute myocardial infarction: the Trent study.

Authors:  R G Wilcox; J R Hampton; D C Banks; J S Birkhead; I A Brooksby; C J Burns-Cox; M J Hayes; M D Joy; A D Malcolm; H G Mather
Journal:  Br Med J (Clin Res Ed)       Date:  1986-11-08

Review 3.  Nifedipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in ischaemic heart disease, hypertension and related cardiovascular disorders.

Authors:  E M Sorkin; S P Clissold; R N Brogden
Journal:  Drugs       Date:  1985-09       Impact factor: 9.546

Review 4.  Calcium antagonists and their mode of action: an historical overview.

Authors:  W G Nayler; J S Dillon
Journal:  Br J Clin Pharmacol       Date:  1986       Impact factor: 4.335

Review 5.  Vasodilator therapy in the perioperative period.

Authors:  P N Fyman; J E Cottrell; L Kushins; P A Casthely
Journal:  Can Anaesth Soc J       Date:  1986-09

6.  Electrocardiography then and now: where next?

Authors:  D M Krikler
Journal:  Br Heart J       Date:  1987-02

7.  Electrophysiological effects of felodipine.

Authors:  M Been; P W Macfarlane; W S Hillis
Journal:  Drugs       Date:  1985       Impact factor: 9.546

Review 8.  Felodipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension.

Authors:  E Saltiel; A G Ellrodt; J P Monk; M S Langley
Journal:  Drugs       Date:  1988-10       Impact factor: 9.546

Review 9.  Verapamil in arrhythmia.

Authors:  D M Krikler
Journal:  Br J Clin Pharmacol       Date:  1986       Impact factor: 4.335

10.  Antihypertensive and metabolic effects of nifedipine and labetalol alone and in combination in primary hypertension.

Authors:  K P Ohman; L Weiner; H von Schenck; B E Karlberg
Journal:  Eur J Clin Pharmacol       Date:  1985       Impact factor: 2.953
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