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Literature DB >> 4862198

Unusual growth characteristics of a methionine-cyano-B12 auxotroph of Escherichia coli.

Abstract

Escherichia coli K-12, strain AB1172, substrain 2276, a methionine(-)-cyano-B(12) (-) auxotroph grew poorly when placed in a medium containing optimal levels of cyano-B(12) and suboptimal amounts of l-methionine. A marked depression of N(5,10)-methylene-H(4)-folate reductase was observed in the inhibited cells, although no significant alterations in other enzymes involved in the metabolism of N(5,10)-methylene-H(4)-folate were observed. Guanosine was effective in preventing the growth inhibition.

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Year: 1967 PMID： 4862198 PMCID： PMC276869 DOI： 10.1128/jb.94.5.1609-1615.1967

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

14 in total

1. Biosynthesis of the purines. XXVI. The identification of the formyl donors of the transformylation reactions.

Authors: S C HARTMAN; J M BUCHANAN
Journal: J Biol Chem Date: 1959-07 Impact factor: 5.157

2. Enzymatic synthesis of the methyl group of methionine. I. Identification of the enzymes and cofactors involved in the system isolated from Escherichia coli.

Authors: F T HATCH; A R LARRABEE; R E CATHOU; J M BUCHANAN
Journal: J Biol Chem Date: 1961-04 Impact factor: 5.157

Unusual growth characteristics of a methionine-cyano-B12 auxotroph of Escherichia coli.

1. Biosynthesis of the purines. XXVI. The identification of the formyl donors of the transformylation reactions.

2. Enzymatic synthesis of the methyl group of methionine. I. Identification of the enzymes and cofactors involved in the system isolated from Escherichia coli.

3. Virus-induced acquisition of metabolic function. I. Enzymatic formation of 5-hydroxymethyldeoxycytidylate.

4. Synthetic prefolic A.

5. Studies on the conversion of deoxyuridylic acid to thymidylic acid by a soluble extract from rat thymus.

6. Protein measurement with the Folin phenol reagent.

7. [The biosynthesis of beta-galactosidase (lactase) in Escherichia coli; the specificity of induction].

8. Altered folate metabolism in a vitamin B 12-methionine auxotroph.

9. Control of one-carbon metabolism in a methionine-B12 auxotroph of Escherichia coli.

10. Inhibition of 5,10-methylenetetrahydrofolate dehydrogenase by purine nucleotides.

1. Isolation of vitamin B 12 transport mutants of Escherichia coli.