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Literature DB >> 486155

On the molecular-weight-dependence of the anticoagulant activity of heparin.

L Thunberg, U Lindahl, A Tengblad, T C Laurent, C M Jackson.

Abstract

The inactivation of thrombin and factor Xa by antithrombin was determined in the presence of heparin fractions of different molecular weights and with high affinity for antithrombin. The ability to potentiate the inactivation of either coagulation factor increased with increasing length of the polysaccharide chain.

Entities: Chemical Gene

Mesh：

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Year: 1979 PMID： 486155 PMCID： PMC1161146 DOI： 10.1042/bj1810241

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

8 in total

1. Anticoagulant properties of heparin fractionated by affinity chromatography on matrix-bound antithrombin iii and by gel filtration.

Authors: L O Andersson; T W Barrowcliffe; E Holmer; E A Johnson; G E Sims
Journal: Thromb Res Date: 1976-12 Impact factor: 3.944

2. The separation of active and inactive forms of heparin.

Authors: L H Lam; J E Silbert; R D Rosenberg
Journal: Biochem Biophys Res Commun Date: 1976-03-22 Impact factor: 3.575

3. Anticoagulant activity of heparin: separation of high-activity and low-activity heparin species by affinity chromatography on immobilized antithrombin.

Authors: M Höök; I Björk; J Hopwood; U Lindahl
Journal: FEBS Lett Date: 1976-07-01 Impact factor: 4.124

4. Anticoagulant activity of heparin: isolation of antithrombin-binding sites.

Authors: J Hopwood; M Höök; A Linker; U Lindahl
Journal: FEBS Lett Date: 1976-10-15 Impact factor: 4.124

5. Studies on bovine factor X. II. Characterization of purified factor X. Observations on some alterations in zone electrophoretic and chromatographic behavior occurring during purification.

Authors: C M Jackson; D J Hanahan
Journal: Biochemistry Date: 1968-12 Impact factor: 3.162

Review 6. Chemistry of the hemostatic mechanism and its relationship to the action of heparin.

Authors: R D Rosenberg
Journal: Fed Proc Date: 1977-01

7. The molecular-weight-dependence of the anti-coagulant activity of heparin.

Authors: T C Laurent; A Tengblad; L Thunberg; M Höök; U Lindahl
Journal: Biochem J Date: 1978-11-01 Impact factor: 3.857

8. A catalytic role for heparin. Evidence for a ternary complex of heparin cofactor thrombin and heparin.

Authors: M W Pomerantz; W G Owen
Journal: Biochim Biophys Acta Date: 1978-07-21

8 in total

11 in total

Review 1. Nadroparin calcium. A review of its pharmacology and clinical use in the prevention and treatment of thromboembolic disorders.

Authors: R Davis; D Faulds
Journal: Drugs Aging Date: 1997-04 Impact factor: 3.923

Review 2. Mechanism of the anticoagulant action of heparin.

Authors: I Björk; U Lindahl
Journal: Mol Cell Biochem Date: 1982-10-29 Impact factor: 3.396

3. The molecular-weight dependence of the rate-enhancing effect of heparin on the inhibition of thrombin, factor Xa, factor IXa, factor XIa, factor XIIa and kallikrein by antithrombin.

Authors: E Holmer; K Kurachi; G Söderström
Journal: Biochem J Date: 1981-02-01 Impact factor: 3.857

4. Dose adjusted heparin treatment of deep venous thrombosis: a comparison of unfractionated and low molecular weight heparin.

Authors: G F Handeland; U Abildgaard; H A Holm; K E Arnesen
Journal: Eur J Clin Pharmacol Date: 1990 Impact factor: 2.953

On the molecular-weight-dependence of the anticoagulant activity of heparin.

1. Anticoagulant properties of heparin fractionated by affinity chromatography on matrix-bound antithrombin iii and by gel filtration.

2. The separation of active and inactive forms of heparin.

3. Anticoagulant activity of heparin: separation of high-activity and low-activity heparin species by affinity chromatography on immobilized antithrombin.

4. Anticoagulant activity of heparin: isolation of antithrombin-binding sites.

5. Studies on bovine factor X. II. Characterization of purified factor X. Observations on some alterations in zone electrophoretic and chromatographic behavior occurring during purification.

Review 6. Chemistry of the hemostatic mechanism and its relationship to the action of heparin.

7. The molecular-weight-dependence of the anti-coagulant activity of heparin.

8. A catalytic role for heparin. Evidence for a ternary complex of heparin cofactor thrombin and heparin.

Review 1. Nadroparin calcium. A review of its pharmacology and clinical use in the prevention and treatment of thromboembolic disorders.

Review 2. Mechanism of the anticoagulant action of heparin.

3. The molecular-weight dependence of the rate-enhancing effect of heparin on the inhibition of thrombin, factor Xa, factor IXa, factor XIa, factor XIIa and kallikrein by antithrombin.

4. Dose adjusted heparin treatment of deep venous thrombosis: a comparison of unfractionated and low molecular weight heparin.

5. Anticoagulant activities of heparin oligosaccharides and their neutralization by platelet factor 4.

6. The relative molecular mass dependence of the anti-factor Xa properties of heparin.

7. Binding of platelet factor 4 to heparin oligosaccharides.

8. Changes in disaccharide composition of heparan sulphate fractions with increasing degrees of sulphation.

9. Antithrombotic properties in rabbits of heparin and heparin fragments covalently coupled to human antithrombin III.

10. The acceleration of the inhibition of platelet prothrombinase complex by heparin.