Literature DB >> 486118

The effect of surgical trauma on muscle protein turnover in rats. A serious methodological misunderstanding.

D J Millward.   

Abstract

The reported rates of protein degradation in a recent paper on the effect of surgical trauma on muscle protein turnover [Hoover-Plow & Clifford (1978) Biochem. J. 176, 137--142] have no real meaning because of a serious methodological misunderstanding by the authors. In addition, there are problems involved in the determination of synthesis rates, so that the reported effects of trauma on muscle protein turnover can be discounted.

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Year:  1979        PMID： 486118      PMCID： PMC1161068          DOI： 10.1042/bj1800427

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  5 in total

1.  Measurement of protein turnover in rat liver. Analysis of the complex curve for decay of label in a mixture of proteins.

Authors:  P J Garlick; J C Waterlow; R W Swick
Journal:  Biochem J       Date:  1976-06-15       Impact factor: 3.857

Review 2.  An appraisal of techniques for the determination of protein turnover in vivo.

Authors:  P J Garlick; D J Millward
Journal:  Proc Nutr Soc       Date:  1972-12       Impact factor: 6.297

3.  Protein turnover in skeletal muscle. II. The effect of starvation and a protein-free diet on the synthesis and catabolism of skeletal muscle proteins in comparison to liver.

Authors:  D J Millward
Journal:  Clin Sci       Date:  1970-11       Impact factor: 6.124

4.  Protein turnover in skeletal muscle. I. The measurement of rates of synthesis and catabolism of skeletal muscle protein using (14C)Na2CO3 to label protein.

Authors:  D J Millward
Journal:  Clin Sci       Date:  1970-11       Impact factor: 6.124

5.  The effect of surgical trauma on muscle protein turnover in rats.

Authors:  J L Hoover-Plow; A J Clifford
Journal:  Biochem J       Date:  1978-10-15       Impact factor: 3.857
  5 in total

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