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Literature DB >> 4858777

Pinocytosis by human alveolar macrophages. Comparison of smokers and nonsmokers.

Abstract

Alveolar macrophages were obtained from human volunteers, smokers and nonsmokers, by bronchial lavage through a fiberoptic bronchoscope. Cells were incubated in a chemically defined medium containing [(14)C]sucrose (0.36 mM) and varying concentrations of rabbit serum. Pinocytosis was assessed by the cellular uptake of isotope over 30, 75, and 120-min periods. Pinocytic activity of smokers' cells was dependent on serum concentration but always less than the activity of nonsmokers' cells. The degree of pinocytosis by nonsmokers' cells was independent of serum concentration. It is concluded that the decreased level of pinocytic activity in smokers' alveolar macrophages as indicated by the uptake of sucrose in the presence of rabbit serum may represent a form of reticuloendothelial blockade.

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Year: 1974 PMID： 4858777 PMCID： PMC301551 DOI： 10.1172/JCI107759

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

27 in total

1. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

2. Altered morphology and increased acid hydrolase content of pulmonary macrophages from cigarette smokers.

Authors: R R Martin
Journal: Am Rev Respir Dis Date: 1973-04

3. Pinocytosis as the cause of sucrose nephrosis.

Authors: S L Schwartz; C B Johnson
Journal: Nephron Date: 1971 Impact factor: 2.847

4. Alveolar macrophages. Structural and functional differences between nonsmokers and smokers of marijuana and tobacco.

Authors: P E Mann; A B Cohen; T N Finley; A J Ladman
Journal: Lab Invest Date: 1971-08 Impact factor: 5.662

5. The ultrastructure of alveolar macrophages from human cigarette smokers and nonsmokers.

Authors: S A Pratt; M H Smith; A J Ladman; T N Finley
Journal: Lab Invest Date: 1971-05 Impact factor: 5.662

6. Low yield of pulmonary surfactant in cigarette smokers.

Authors: T N Finley; A J Ladman
Journal: N Engl J Med Date: 1972-02-03 Impact factor: 91.245

7. Ion and macromolecular transport in the alveolar macrophage.

Authors: E D Robin; J D Smith; A R Tanser; J S Adamson; J E Millen; B Packer
Journal: Biochim Biophys Acta Date: 1971-07-06

8. Cigarette smoking and acute non-influenzal respiratory disease in military cadets.

Authors: J F Finklea; V Hasselblad; S H Sandifer; D I Hammer; G R Lowrimore
Journal: Am J Epidemiol Date: 1971-06 Impact factor: 4.897

9. The human alveolar macrophage: isolation, cultivation in vitro, and studies of morphologic and functional characteristics.

Authors: A B Cohen; M J Cline
Journal: J Clin Invest Date: 1971-07 Impact factor: 14.808

10. Endocytosis in Chang liver cells. Quantitation by sucrose- 3 H uptake and inhibition by cytochalasin B.

Authors: R Wagner; M Rosenberg; R Estensen
Journal: J Cell Biol Date: 1971-09 Impact factor: 10.539

11 in total

Review 1. Cigarette smoking and reactions to air pollutants.

Authors: R J Shephard
Journal: Can Med Assoc J Date: 1978-02-18 Impact factor: 8.262

2. Ultrastructural examination of broncho-alveolar lavage for diagnosis of pulmonary histiocytosis X: Preliminary report on 4 cases.

Authors: F Basset; P Soler; M C Jaurand; J Bignon
Journal: Thorax Date: 1977-06 Impact factor: 9.139

Pinocytosis by human alveolar macrophages. Comparison of smokers and nonsmokers.

1. Protein measurement with the Folin phenol reagent.

2. Altered morphology and increased acid hydrolase content of pulmonary macrophages from cigarette smokers.

3. Pinocytosis as the cause of sucrose nephrosis.

4. Alveolar macrophages. Structural and functional differences between nonsmokers and smokers of marijuana and tobacco.

5. The ultrastructure of alveolar macrophages from human cigarette smokers and nonsmokers.

6. Low yield of pulmonary surfactant in cigarette smokers.

7. Ion and macromolecular transport in the alveolar macrophage.

8. Cigarette smoking and acute non-influenzal respiratory disease in military cadets.

9. The human alveolar macrophage: isolation, cultivation in vitro, and studies of morphologic and functional characteristics.

10. Endocytosis in Chang liver cells. Quantitation by sucrose- 3 H uptake and inhibition by cytochalasin B.

Review 1. Cigarette smoking and reactions to air pollutants.

2. Ultrastructural examination of broncho-alveolar lavage for diagnosis of pulmonary histiocytosis X: Preliminary report on 4 cases.

3. The role of elastases in the development of emphysema.

4. Bronchoalveolar lavage.

5. Modulation of mitogen-induced proliferation of autologous peripheral blood lymphocytes by human alveolar macrophages.

6. Inflammatory and immune processes in the human lung in health and disease: evaluation by bronchoalveolar lavage.

7. Diagnosis of pulmonary histiocytosis X by immunodetection of Langerhans cells in bronchoalveolar lavage fluid.

8. Specificity of opsonic antibodies to enhance phagocytosis of Pseudomonas aeruginosa by human alveolar macrophages.

9. Antibiotic uptake by alveolar macrophages of smokers.

10. Human alveolar macrophages: effects of endotoxin in vitro.