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Literature DB >> 4854485

Studies on the heparin sulphamidase activity from rat spleen. Intracellular distribution and characterization of the enzyme.

Abstract

A sulphamidase activity present in rat spleen capable of hydrolysing N-[(35)S]sulphated heparin was studied. This activity was associated with the lysosomal fraction. Studies in vivo showed that the rat is capable of significantly desulphating heparin. Lysosomes in all the major tissues can effectively accumulate heparin. The heparin sulphamidase and arylsulphatase activities from rat spleen were separated by isoelectric focusing. Heparin sulphamidase was a distinct entity from all the arylsulphatase activities.

Entities: Chemical Species

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Year: 1974 PMID： 4854485 PMCID： PMC1166333 DOI： 10.1042/bj1390699

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

19 in total

1. Tissue fractionation studies. 4. Comparative study of the binding of acid phosphatase, beta-glucuronidase and cathepsin by rat-liver particles.

Authors: R GIANETTO; C DE DUVE
Journal: Biochem J Date: 1955-03 Impact factor: 3.857

2. The sulphatase of ox liver. 7. The intracellular distribution of sulphatases A and B.

Authors: A B ROY
Journal: Biochem J Date: 1960-11 Impact factor: 3.857

3. A method for determining the sedimentation behavior of enzymes: application to protein mixtures.

Authors: R G MARTIN; B N AMES
Journal: J Biol Chem Date: 1961-05 Impact factor: 5.157

4. Tissue fractionation studies. 12. Intracellular distribution of some dehydrogenases, alkaline deoxyribonuclease and iron in rat-liver tissue.

Authors: H BEAUFAY; D S BENDALL; P BAUDHUIN; C DE DUVE
Journal: Biochem J Date: 1959-12 Impact factor: 3.857

5. Tissue fractionation studies. 15. Intracellular distribution and properties of beta-N-acetylglucosaminidase and beta-galactosidase in rat liver.

Authors: O Z SELLINGER; H BEAUFAY; P JACQUES; A DOYEN; C DE DUVE
Journal: Biochem J Date: 1960-03 Impact factor: 3.857

6. Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue.

Authors: C DE DUVE; B C PRESSMAN; R GIANETTO; R WATTIAUX; F APPELMANS
Journal: Biochem J Date: 1955-08 Impact factor: 3.857

7. Chemical and pharmacological studies on N-resulfated heparin.

Authors: L LEVY; F J PETRACEK
Journal: Proc Soc Exp Biol Med Date: 1962-04

8. A microspectrophotometric method for the determination of cytochrome oxidase.

Authors: S J COOPERSTEIN; A LAZAROW
Journal: J Biol Chem Date: 1951-04 Impact factor: 5.157

9. Protein catabolism in rat liver homogenates. A re-evaluation of the energy requirement for protein catabolism.

Authors: C O Brostrom; H Jeffay
Journal: J Biol Chem Date: 1970-08-25 Impact factor: 5.157

10. Lysosomes in lymphoid tissue. I. The measurement of hydrolytic activities in whole homogenates.

Authors: W E Bowers; J T Finkenstaedt; C de Duve
Journal: J Cell Biol Date: 1967-02 Impact factor: 10.539

7 in total

Review 1. Parenteral anticoagulants: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

Authors: David A Garcia; Trevor P Baglin; Jeffrey I Weitz; Meyer Michel Samama
Journal: Chest Date: 2012-02 Impact factor: 9.410

Studies on the heparin sulphamidase activity from rat spleen. Intracellular distribution and characterization of the enzyme.

1. Tissue fractionation studies. 4. Comparative study of the binding of acid phosphatase, beta-glucuronidase and cathepsin by rat-liver particles.

2. The sulphatase of ox liver. 7. The intracellular distribution of sulphatases A and B.

3. A method for determining the sedimentation behavior of enzymes: application to protein mixtures.

4. Tissue fractionation studies. 12. Intracellular distribution of some dehydrogenases, alkaline deoxyribonuclease and iron in rat-liver tissue.

5. Tissue fractionation studies. 15. Intracellular distribution and properties of beta-N-acetylglucosaminidase and beta-galactosidase in rat liver.

6. Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue.

7. Chemical and pharmacological studies on N-resulfated heparin.

8. A microspectrophotometric method for the determination of cytochrome oxidase.

9. Protein catabolism in rat liver homogenates. A re-evaluation of the energy requirement for protein catabolism.

10. Lysosomes in lymphoid tissue. I. The measurement of hydrolytic activities in whole homogenates.

Review 1. Parenteral anticoagulants: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

2. The mucopolysaccharidoses.

3. Oral heparin results in the appearance of heparin fragments in the plasma of rats.

4. Heparin and enoxaparin enhance endotoxin-induced tumor necrosis factor-alpha production in human monocytes.

5. Aluminofluorides and beryllofluorides as inhibitors of sulphatases. Analogues of hydrogen sulphate?

6. The catabolism of intravenously injected heparan N-[35S] sulphate in the rat.

7. Multiple forms of 2-deoxy-D-glucoside-2-sulphamate sulphohydrolase from human placenta.