| Literature DB >> 4843378 |
Abstract
The potent antileukemic plant principles triptolide and tripdiolide contain a characteristic hydrogen-bonded 9,11-epoxy-14beta-hydroxy system. They alkylate propanethiol in a process which involves opening of the epoxide function with neighboring hydroxyl assistance. The reaction may mimic the inhibition of tumor growth via selective alkylation of the thiol groups of key enzymes concerned with groth regulation.Entities:
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Year: 1974 PMID： 4843378 DOI： 10.1126/science.185.4153.791
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728