| Literature DB >> 4841583 |
M Bulat, Z Lacković, M Jakupcevic, I Damjanov.
Abstract
In cats, 19 days after the lower thoracic cord was injllred, the concentrations of 5-hydroxytryptamine and its metabolite 5-hydroxyindoleacetic acid in the lumbosacral cord and that of 5-hydroxyindoleacetic acid in the lumbar fluid decreased. At the same time the concentrations of these substances in the cord above the lesion and that of 5-hydroxyindoleacetic acid in the cisternal fluid was not significantly altered. Since high concentrations of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid are present in the human lumbosacral cord, it appears that the concentration of 5-hydroxyincdoleacetic acid in the lumbar fluid of animals and man reflects the biochemical changes of 5-hydroxytryptamine in the spinal cord.Entities:
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Year: 1974 PMID： 4841583 DOI： 10.1126/science.185.4150.527
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728