Literature DB >> 4836755

Effects of ergotamine and methysergide on blood platelet aggregation responses of migrainous subjects.

B P Hilton, K J Zilkha.   

Abstract

Platelet aggregation responses to 5-hydroxytryptamine (5-HT) were measured in plasma from migrainous subjects taking either methysergide maleate or ergotamine tartrate and were found to be reduced. Blood 5-HT levels of subjects free of headache were not affected by these drugs. The results support the hypothesis that methysergide and ergotamine act by occupying 5-HT uptake sites in vessel walls, leaving 5-HT molecules available to occupy receptors concerned with vasoconstriction.

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Year:  1974        PMID： 4836755      PMCID： PMC494705          DOI： 10.1136/jnnp.37.5.593

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  13 in total

1.  ESTIMATION OF 5-HYDROXYTRYPTAMINE IN HUMAN BLOOD.

Authors:  G W ASHCROFT; T B CRAWFORD; J K BINNS; E J MACDOUGALL
Journal:  Clin Chim Acta       Date:  1964-04       Impact factor: 3.786

2.  METHYSERGIDE FOR PREVENTION OF HEADACHE; EXPERIENCE IN FIVE HUNDRED PATIENTS OVER THREE YEARS.

Authors:  J R GRAHAM
Journal:  N Engl J Med       Date:  1964-01-09       Impact factor: 91.245

3.  [THE "THRESHOLD OF SENSITIVITY TO SEROTONIN" IN NORMAL AND PATHOLOGIC CONDITIONS. PRELIMINARY NOTE].

Authors:  M GIACOVAZZO; A BUTTI; R DESANTIS
Journal:  Folia Allergol (Roma)       Date:  1965 Jan-Feb

4.  Effects of 5-hydroxytryptamine on platelet aggregation.

Authors:  H R Baumgartner; G V Born
Journal:  Nature       Date:  1968-04-13       Impact factor: 49.962

5.  [Effect of ergotamine tartrate on urinary excretion of 5-hydroxyindoleacetic acid].

Authors:  F Farris; A Rappelli; I Mathis
Journal:  Boll Soc Ital Biol Sper       Date:  1967-03-31

6.  Effect of Serpasil, Niamid and Deseril on the excretion of 5-hydroxyindoloacetic acid in diurnal urine and on oxidase activity of ceruloplasmin in human serum.

Authors:  J Pokora
Journal:  Pol Med J       Date:  1966

7.  Comparative trial of serotonin antagonists in the management of migraine.

Authors:  J W Lance; M Anthony; B Somerville
Journal:  Br Med J       Date:  1970-05-09

8.  An assessment of platelet aggregation induced by 5-hydroxytryptamine.

Authors:  B P Hilton; J N Cumings
Journal:  J Clin Pathol       Date:  1971-04       Impact factor: 3.411

9.  5-Hydroxytryptamine levels and platelet aggregation responses in subjects with acute migraine headache.

Authors:  B P Hilton; J N Cumings
Journal:  J Neurol Neurosurg Psychiatry       Date:  1972-08       Impact factor: 10.154

10.  Effects of methysergide on platelets incubated with reserpine.

Authors:  J N Cumings; B P Hilton
Journal:  Br J Pharmacol       Date:  1971-08       Impact factor: 8.739
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  2 in total

1.  Measurement of activity of 5-HT antagonists following oral administration in man: a comparison of methysergide and BW501.

Authors:  J O'Grady; E Peringer; G John
Journal:  Br J Clin Pharmacol       Date:  1979-02       Impact factor: 4.335

2.  [Clinical aspects of pathophysiological mechanisms in migraine.].

Authors:  K H Grotemeyer; I W Husstedt; H P Schlake
Journal:  Schmerz       Date:  1989-12       Impact factor: 1.107
  2 in total

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