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Literature DB >> 4834555

A study of peripheral leucocyte migration in agarose medium in inflammatory bowel disease.

Abstract

THE MIGRATION OF PERIPHERAL LEUCOCYTES FROM PATIENTS WITH INFLAMMATORY BOWEL DISEASE WAS INVESTIGATED USING AN AGAROSE PLATE TECHNIQUE AND THREE ANTIGENIC MATERIALS: (1) the enterobacterial common antigen of Kunin; (2) extract from germ-free rat faeces; and (3) Kveim suspension from a sarcoid spleen K19. Inhibition of migration was obtained only with Kunin antigen. It was present in 11 out of 20 patients with ulcerative colitis and in four out of 20 patients with Crohn's disease but in only one out of 33 control subjects. These findings suggest the possibility that a state of cellular immunity to enterobacterial common antigen may exist in inflammatory bowel disease. Lack of cellular reactivity to extract from germ-free faeces and Kveim suspension is in contrast with the results obtained by others by means of the capillary tube method and requires further investigation.

Entities: Chemical Disease Species

Mesh：

Substances：
Antigens, Bacterial

Year: 1974 PMID： 4834555 PMCID： PMC1412952 DOI： 10.1136/gut.15.4.294

Source DB: PubMed Journal: Gut ISSN： 0017-5749 Impact factor: 23.059

18 in total

1. Immunological studies in ulcerative colitis. V. Family studies.

Authors: R Lagercrantz; P Perlmann; S Hammarström
Journal: Gastroenterology Date: 1971-03 Impact factor: 22.682

2. Tuberculin-induced migration inhibition of human peripheral leucocytes in agarose medium.

Authors: J E Clausen
Journal: Acta Allergol Date: 1971-02

3. Escherichia Coli O:14 and colon hemagglutinating antibodies in inflammatory bowel disease.

Authors: W R Thayer; M Brown; M H Sangree; J Katz; T Hersh
Journal: Gastroenterology Date: 1969-09 Impact factor: 22.682

4. Antigen from colon of germfree rats and antibodies in human ulcerative colitis.

Authors: P Perlmann; S Hammarström; R Lagercrantz; B E Gustafsson
Journal: Ann N Y Acad Sci Date: 1965-06-30 Impact factor: 5.691

5. Delayed hypersensitivity in Crohn's disease.

Authors: P W Dykes
Journal: Proc R Soc Med Date: 1970-09

6. Further studies on in vitro cytotoxicity of lymphocytes from patients with ulcerative and granulomatous colitis for allogeneic colonic epithelial cells, including the effects of colectomy.

Authors: R G Shorter; M Cardoza; R J Spencer; K A Huizenga
Journal: Gastroenterology Date: 1969-02 Impact factor: 22.682

7. Cellular hypersensitivity to components of intestinal mucosa in ulcerative colitis and Crohn's disease.

Authors: G Bendixen
Journal: Gut Date: 1969-08 Impact factor: 23.059

8. Effect of lymphocytes from patients with ulcerative colitis on human adult colon epithelial cells.

Authors: D W Watson; A Quigley; R J Bolt
Journal: Gastroenterology Date: 1966-12 Impact factor: 22.682

9. Immunological studies in ulcerative colitis. IV. Origin of autoantibodies.

Authors: R Lagercrantz; S Hammarström; P Perlmann; B E Gustafsson
Journal: J Exp Med Date: 1968-12-01 Impact factor: 14.307

10. Immunological studies in ulcerative colitis. II. "Colon" antigen and human blood group A- and H-like antigens in germfree rats.

Authors: S Hammarström; R Lagercrantz; P Perlmann; B E Gustafsson
Journal: J Exp Med Date: 1965-12-01 Impact factor: 14.307

12 in total

1. Studies on the subpopulation and function of peripheral lymphocytes, and lymphocyte reactivity to colonic mucosal antigen and bacterial antigen in patients with ulcerative colitis and Crohn's disease.

Authors: K Kobayashi; A Kitano; S Mizuno; K Yamaguchi; Y Mizoguchi
Journal: Gastroenterol Jpn Date: 1978

A study of peripheral leucocyte migration in agarose medium in inflammatory bowel disease.

1. Immunological studies in ulcerative colitis. V. Family studies.

2. Tuberculin-induced migration inhibition of human peripheral leucocytes in agarose medium.

3. Escherichia Coli O:14 and colon hemagglutinating antibodies in inflammatory bowel disease.

4. Antigen from colon of germfree rats and antibodies in human ulcerative colitis.

5. Delayed hypersensitivity in Crohn's disease.

6. Further studies on in vitro cytotoxicity of lymphocytes from patients with ulcerative and granulomatous colitis for allogeneic colonic epithelial cells, including the effects of colectomy.

7. Cellular hypersensitivity to components of intestinal mucosa in ulcerative colitis and Crohn's disease.

8. Effect of lymphocytes from patients with ulcerative colitis on human adult colon epithelial cells.

9. Immunological studies in ulcerative colitis. IV. Origin of autoantibodies.

10. Immunological studies in ulcerative colitis. II. "Colon" antigen and human blood group A- and H-like antigens in germfree rats.

1. Studies on the subpopulation and function of peripheral lymphocytes, and lymphocyte reactivity to colonic mucosal antigen and bacterial antigen in patients with ulcerative colitis and Crohn's disease.

2. Decreased suppressor cell activity in inflammatory bowel disease.

Review 3. The immunologic basis of inflammatory bowel disease.

4. Oral manifestations of Crohn's disease: studies in the pathogenesis.

5. Abnormalities of B-cell activation and immunoregulation in patients with Crohn's disease.

6. Alteration in T lymphocyte subpopulations in inflammatory bowel disease.

Review 7. Idiopathic Inflammation Bowel Disease: is there a role for immunological mechanisms in etiopathogenesis?

8. Spontaneous suppressor cell function in inflammatory bowel disease.

9. Actions of anticolitic drugs on a guinea-pig model of immune colitis.

10. Chronic immune colitis in rabbits.