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Literature DB >> 4833964

Degree and duration of reversal by naloxone of effects of morphine in conscious subjects.

Abstract

The effects of intravenous naloxone on several of the actions of intravenous morphine (mean dose 30 mg/70 kg) were studied in six volunteer subjects. Naloxone produced a well defined reversal of the respiratory depression, analgesia, and miotic and subjective effects of the morphine. The agonist action of morphine outlasted the antagonist action of a single dose of naloxone. The effect of repeated doses of naloxone was also short-lived, but continuous infusions were effective in maintaining reversal.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1974 PMID： 4833964 PMCID： PMC1610781 DOI： 10.1136/bmj.2.5919.589

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

11 in total

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19 in total

Review 1. Naloxone in opioid poisoning: walking the tightrope.

Authors: S F J Clarke; P I Dargan; A L Jones
Journal: Emerg Med J Date: 2005-09 Impact factor: 2.740

Review 2. Naloxone dosage for opioid reversal: current evidence and clinical implications.

Authors: Rachael Rzasa Lynn; J L Galinkin
Journal: Ther Adv Drug Saf Date: 2017-12-13

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Journal: Br Med J Date: 1977-07-23

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6. Naloxone Dosing After Opioid Overdose in the Era of Illicitly Manufactured Fentanyl.

Authors: Joseph Carpenter; Brian Patrick Murray; Sukhshant Atti; Tim P Moran; Arthur Yancey; Brent Morgan
Journal: J Med Toxicol Date: 2019-08-30

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Review 10. An Introduction to the Endogenous Cannabinoid System.

Authors: Hui-Chen Lu; Ken Mackie
Journal: Biol Psychiatry Date: 2015-10-30 Impact factor: 13.382