Literature DB >> 483124

Characterization of naturally occurring auxotrophic mammalian cells.

S L Naylor, J K Townsend, R J Klebe.   

Abstract

In a previous study, several cultured cell lines were detected which are naturally occurring auxotrophs. In this investigation, the enzyme deficienceis involved are described. It is demonstrated that the Chinese hamster cell lines CHO(K1), YH21, RJK-36, and CHW-1102 are deficient in cystathionase and argininosuccinate synthetase. In addition, CHO (K1) and CHW-1102 were found to lack argininosuccinate lyase. CHW-1102 cells were also found to be unable to proliferate in medium containing branched-chain alpha-keto acids in place of the corresponding L-amino acids since CHW-1102 cells lack branched-chain aminotransferase.

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Year:  1979        PMID： 483124     DOI： 10.1007/bf01539166

Source DB:  PubMed          Journal:  Somatic Cell Genet        ISSN： 0098-0366


  3 in total

1.  A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism.

Authors:  Hooman Hefzi; Kok Siong Ang; Michael Hanscho; Aarash Bordbar; David Ruckerbauer; Meiyappan Lakshmanan; Camila A Orellana; Deniz Baycin-Hizal; Yingxiang Huang; Daniel Ley; Veronica S Martinez; Sarantos Kyriakopoulos; Natalia E Jiménez; Daniel C Zielinski; Lake-Ee Quek; Tune Wulff; Johnny Arnsdorf; Shangzhong Li; Jae Seong Lee; Giuseppe Paglia; Nicolas Loira; Philipp N Spahn; Lasse E Pedersen; Jahir M Gutierrez; Zachary A King; Anne Mathilde Lund; Harish Nagarajan; Alex Thomas; Alyaa M Abdel-Haleem; Juergen Zanghellini; Helene F Kildegaard; Bjørn G Voldborg; Ziomara P Gerdtzen; Michael J Betenbaugh; Bernhard O Palsson; Mikael R Andersen; Lars K Nielsen; Nicole Borth; Dong-Yup Lee; Nathan E Lewis
Journal:  Cell Syst       Date:  2016-11-23       Impact factor: 10.304

2.  Localization of a gene which complements branched-chain amino acid transaminase deficiency to the short arm of human chromosome 12.

Authors:  C Jones; E E Moore
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

3.  Expression of the human argininosuccinate synthetase gene in hamster transferents.

Authors:  L D Hudson; R W Erbe; L B Jacoby
Journal:  Proc Natl Acad Sci U S A       Date:  1980-07       Impact factor: 11.205
  3 in total

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