Literature DB >> 4827105

Indomethacin and platelet aggregation in chronic glomerulonephritis: existence of non-responders.

G De Gaetano, J Vermylen, M B Donati, G Dotremont, P Michielsen.   

Abstract

Indomethacin given to adults with glomerulonephritis usually reduces their urinary excretion of protein and fibrinogen/fibrin-related (F.R.) antigen. Nevertheless, non-responders exist. Platelet aggregation is significantly more strongly inhibited by indomethacin in good responders than in nonresponders. This supports the hypothesis that the reduction of urinary excretion of F.R. antigen during indomethacin administration is related, at least in part, to inhibition of intrarenal platelet aggregation and of the subsequent fibrin deposition.

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Year:  1974        PMID： 4827105      PMCID： PMC1610962          DOI： 10.1136/bmj.2.5914.301

Source DB:  PubMed          Journal:  Br Med J        ISSN： 0007-1447


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8.  Pharmacological modification of urinary excretion of fibrinogen-like material in glomerulonephritis.

Authors:  J Vermylen; G Dotremont; M B Donati; G De Gaetano; P Michielsen
Journal:  Scand J Haematol Suppl       Date:  1971

9.  Indomethacin and urinary excretion of fibrinogen-like material in proliferative glomerulonephritis.

Authors:  J Vermylen; G Dotremont; G de Gaetano; M B Donati; P Michielsen
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