Literature DB >> 4822733

Synthesis of radioactive dolichol from (4S-3H)mevalonate in the regenerating rat liver.

H G Martin, K J Thorne.   

Abstract

The dolichol of rat liver was labelled by injecting [4S-(3)H]mevalonate, the precursor of cis-isoprene residues, into partially hepatectomized animals. The optimum conditions for labelling the dolichol were to inject the animals with radioactive mevalonate 48h after hepatectomy and to kill them 12h later. The concentration of radioactive dolichol was five times as great in regenerating rat liver as in normal liver. The highest concentration of radioactive dolichol was found in the crude mitochondrial and nuclear-debris fractions of the cell. The crude microsomal fractions also contained radioactive dolichol, but at a lower concentration.

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Year:  1974        PMID： 4822733      PMCID： PMC1166204          DOI： 10.1042/bj1380277

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  14 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  3-Polyprenyl-4-hydroxybenzoate synthesis in the inner membrane of mitochondria from p-hydroxybenzoate and isopentenylpyrophosphate. A demonstration of isoprenoid synthesis in rat liver mitochondria.

Authors:  K Momose; H Rudney
Journal:  J Biol Chem       Date:  1972-06-25       Impact factor: 5.157

3.  Studies on the biosynthesis of cholesterol XIX. Steric course of hydrogen eliminations and of C-C bond formations in squalene biosynthesis.

Authors:  J W Cornforth; R H Cornforth; C Donninger; G Popják
Journal:  Proc R Soc Lond B Biol Sci       Date:  1966-01-18

4.  Isolation of rough and smooth microsomes from rat liver by means of a commerically available centrifuge.

Authors:  A Bergstrand; G Dallner
Journal:  Anal Biochem       Date:  1969-06       Impact factor: 3.365

5.  Intracellular distribution of the free and esterified forms of dolichol in pig liver.

Authors:  P H Butterworth; F W Hemming
Journal:  Arch Biochem Biophys       Date:  1968-11       Impact factor: 4.013

6.  In vivo incorporation of [2-14-C]-mevalonate into dolichol of rabbit and pig liver.

Authors:  P H Butterworth; H H Draper; F W Hemming; R A Morton
Journal:  Arch Biochem Biophys       Date:  1966-03       Impact factor: 4.013

7.  The involvement of endogenous dolichol in the formation of lipid-linked precursors of glycoprotein in rat liver.

Authors:  H G Martin; K J Thorne
Journal:  Biochem J       Date:  1974-02       Impact factor: 3.857

8.  Isolation of chick intestinal nuclei. Effect of vitamin D3 on nuclear metabolism.

Authors:  D E Lawson; P W Wilson; D C Barker; E Kodicek
Journal:  Biochem J       Date:  1969-11       Impact factor: 3.857

9.  The characterization and stereochemistry of biosynthesis of dolichols in rat liver.

Authors:  D P Gough; F W Hemming
Journal:  Biochem J       Date:  1970-06       Impact factor: 3.857

10.  The structure of bactoprenol, a lipid formed by lactobacilli from mevalonic acid.

Authors:  K J Thorne; E Kodicek
Journal:  Biochem J       Date:  1966-04       Impact factor: 3.857
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  6 in total

1.  Biosynthesis of dolichyl phosphate: characterization and site of synthesis in algae.

Authors:  H E Hopp; G R Daleo; P A Romero; R P Lezica
Journal:  Plant Physiol       Date:  1978-02       Impact factor: 8.340

2.  Activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase does not respond to ubiquinone uptake in cultured cells.

Authors:  W A Maltese; J R Aprille; R A Green
Journal:  Biochem J       Date:  1987-09-01       Impact factor: 3.857

3.  Determination of arrangement of isoprene units in pig liver dolichol by 13C-n.m.r. spectroscopy.

Authors:  Y Tanaka; H Sato; A Kageyu; T Tomita
Journal:  Biochem J       Date:  1987-04-15       Impact factor: 3.857

4.  Suppression of murine neuroblastoma growth in vivo by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

Authors:  W A Maltese; R Defendini; R A Green; K M Sheridan; D K Donley
Journal:  J Clin Invest       Date:  1985-11       Impact factor: 14.808

5.  The involvement of endogenous dolichol in the formation of lipid-linked precursors of glycoprotein in rat liver.

Authors:  H G Martin; K J Thorne
Journal:  Biochem J       Date:  1974-02       Impact factor: 3.857

6.  Modulation of the mevalonate pathway and cell growth by pravastatin and d-limonene in a human hepatoma cell line (Hep G2).

Authors:  S Kawata; T Nagase; E Yamasaki; H Ishiguro; Y Matsuzawa
Journal:  Br J Cancer       Date:  1994-06       Impact factor: 7.640
  6 in total

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