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Literature DB >> 4821957

Thiocarbamate sulfoxides: potent, selective, and biodegradable herbicides.

Abstract

Sulfoxidation of thiocarbamates yields a new class of chemicals having increased herbicidal activity along with greater tolerance of corn and soybeans in greenhouse tests. However, their thermal stability is not favorable. These sulfoxides are intermediates in the mammalian metabolism of thiocarbamates, being formed by liver microsomal oxidases and cleaved in a system consisting of glutathione and a soluble enzyme from liver.

Entities: Chemical Species

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Year: 1974 PMID： 4821957 DOI： 10.1126/science.184.4136.573

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

9 in total

1. Relative inhibitory potency of molinate and metabolites with aldehyde dehydrogenase 2: implications for the mechanism of enzyme inhibition.

Authors: Erin M G Allen; David G R Anderson; Virginia R Florang; May Khanna; Thomas D Hurley; Jonathan A Doorn
Journal: Chem Res Toxicol Date: 2010-10-18 Impact factor: 3.739

2. Inhibition of rat brain and human red cell acetylcholinesterase by thiocarbamate herbicides.

Authors: Edward A Lock
Journal: Toxicol Res (Camb) Date: 2020-08-28 Impact factor: 3.524

3. Development of PBPK model of molinate and molinate sulfoxide in rats and humans.

Authors: Andrew Campbell
Journal: Regul Toxicol Pharmacol Date: 2009-01-23 Impact factor: 3.271

4. Synthesis and herbicidal activity of 3-{[(hetero)aryl]methanesulfonyl}-4,5-dihydro-1,2-oxazole derivative; Discovery of the novel pre-emergence herbicide pyroxasulfone.

Authors: Masao Nakatani; Minoru Ito; Takumi Yoshimura; Masahiro Miyazaki; Ryohei Ueno; Hiroshi Kawasaki; Satoru Takahashi; Yasushi Todoroki
Journal: J Pestic Sci Date: 2016-11-20 Impact factor: 1.519

Thiocarbamate sulfoxides: potent, selective, and biodegradable herbicides.

1. Relative inhibitory potency of molinate and metabolites with aldehyde dehydrogenase 2: implications for the mechanism of enzyme inhibition.

2. Inhibition of rat brain and human red cell acetylcholinesterase by thiocarbamate herbicides.

3. Development of PBPK model of molinate and molinate sulfoxide in rats and humans.

4. Synthesis and herbicidal activity of 3-{[(hetero)aryl]methanesulfonyl}-4,5-dihydro-1,2-oxazole derivative; Discovery of the novel pre-emergence herbicide pyroxasulfone.

5. Development of the novel pre-emergence herbicide pyroxasulfone.

Review 6. Comparative aspects of pesticide metabolism in plants and animals.

7. Living Polymerization of 2-Ethylthio-2-oxazoline and Postpolymerization Diversification.

Review 8. Phenylthiocarbamate or N-carbothiophenyl group chemistry in peptide synthesis and bioconjugation.

9. New Lead Discovery of Herbicide Safener for Metolachlor Based on a Scaffold-Hopping Strategy.