Literature DB >> 4821240

Survival at extreme altitude: protective effect of increased hemoglobin-oxygen affinity.

J W Eaton, T D Skelton, E Berger.   

Abstract

Decreased hemoglobin-oxygen affinity is thought to be of adaptive value to humans and nonindigenous animals at high altitude. To test this, hemoglobin-oxygen affinity was modified by carbamoylation of hemoglobin in rats. Exposure of control (low oxygen affinity) and experimental (high oxygen affinity) animals to a pressure equivalent to high altitude revealed that increased, rather than decreased, hemoglobin-oxygen affinity will permit survival at greatly reduced environmental oxygen pressures.

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Year:  1974        PMID： 4821240     DOI： 10.1126/science.183.4126.743

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  30 in total

Review 1.  Phenotypic plasticity and genetic adaptation to high-altitude hypoxia in vertebrates.

Authors:  Jay F Storz; Graham R Scott; Zachary A Cheviron
Journal:  J Exp Biol       Date:  2010-12-15       Impact factor: 3.312

2.  Sherpas living permanently at high altitutde: a new pattern of adaptation.

Authors:  G Morpurgo; P Arese; A Bosia; G P Pescarmona; M Luzzana; G Modiano; S Krishna ranjit
Journal:  Proc Natl Acad Sci U S A       Date:  1976-03       Impact factor: 11.205

3.  Hemoglobin function and allosteric regulation in semi-fossorial rodents (family Sciuridae) with different altitudinal ranges.

Authors:  Inge G Revsbech; Danielle M Tufts; Joana Projecto-Garcia; Hideaki Moriyama; Roy E Weber; Jay F Storz; Angela Fago
Journal:  J Exp Biol       Date:  2013-11-15       Impact factor: 3.312

4.  The influence of the position of the oxygen dissociation curve on oxygen-dependent functions of the isolated perfused rat liver. I. Studies at different levels of hypoxic hypoxia.

Authors:  J C Bakker; G C Gortmaker; A C Vrolijk; F G Offerijns
Journal:  Pflugers Arch       Date:  1976-03-11       Impact factor: 3.657

5.  Phenotypic plasticity in blood-oxygen transport in highland and lowland deer mice.

Authors:  Danielle M Tufts; Inge G Revsbech; Zachary A Cheviron; Roy E Weber; Angela Fago; Jay F Storz
Journal:  J Exp Biol       Date:  2012-12-13       Impact factor: 3.312

6.  Influence of high affinity haemoglobin on the response to normoxic and hypoxic exercise.

Authors:  Paolo B Dominelli; Chad C Wiggins; Sarah E Baker; John R A Shepherd; Shelly K Roberts; Tuhin K Roy; Timothy B Curry; James D Hoyer; Jennifer L Oliveira; Michael J Joyner
Journal:  J Physiol       Date:  2020-02-11       Impact factor: 5.182

7.  Human llamas: adaptation to altitude in subjects with high hemoglobin oxygen affinity.

Authors:  R P Hebbel; J W Eaton; R S Kronenberg; E D Zanjani; L G Moore; E M Berger
Journal:  J Clin Invest       Date:  1978-09       Impact factor: 14.808

8.  Improvement of tissue oxygenation during a 20 days-stay at moderate altitutde in connection with mild exercise.

Authors:  E Humpeler; K Inama; P Deetjen
Journal:  Klin Wochenschr       Date:  1979-03-15

9.  Higher oxygen affinity of sheep Hb C compared to Hb A and Hb B.

Authors:  A M Vaccaro-Torracca; R Vestri; S Salmaso
Journal:  Experientia       Date:  1980-05-15

10.  Temporal pattern of erythropoietin titers in kidney tissue during hypoxic hypoxia.

Authors:  W Jelkmann
Journal:  Pflugers Arch       Date:  1982-03       Impact factor: 3.657
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