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Literature DB >> 4818266

Alpha-hydroxyacid oxidase genetics in the mouse: evidence for two genetic loci and a tetrameric subunit structure for the liver isozyme.

Abstract

We have examined a polymorphism for liver GOX in inbred strains of the mouse Mus musculus. Genetic studies demonstrated that the two phenotypes for this enzyme present in BALB/C and NZC parental strains segregated as though they were controlled by codominant alleles at a single autosomal locus (GOX) which mapped closely to the agouti locus in linkage group V. Kidney HAOX activity is invariant in these inbred strains and is encoded by a separate genetic locus designated HAOX. BALB/C x NZC F(1) hybrid mice exhibited three intermediate forms of liver GOX activity, in addition to the parental enzymes, which is consistent with a tetrameric subunit structure.

Entities: Gene Species

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Year: 1974 PMID： 4818266 PMCID： PMC1213057

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

12 in total

10. The large-scale separation of peroxisomes, mitochondria, and lysosomes from the livers of rats injected with triton WR-1339. Improved isolation procedures, automated analysis, biochemical and morphological properties of fractions.

Authors: F Leighton; B Poole; H Beaufay; P Baudhuin; J W Coffey; S Fowler; C De Duve
Journal: J Cell Biol Date: 1968-05 Impact factor: 10.539

10 in total

Review 1. Mouse chromosome 2.

Authors: L D Siracusa; C M Abbott
Journal: Mamm Genome Date: 1992 Impact factor: 2.957

Review 2. Mouse chromosome 2.

Authors: L D Siracusa; C M Abbott
Journal: Mamm Genome Date: 1991 Impact factor: 2.957

Review 3. Mouse map of paralogous genes.

Authors: J H Nadeau; M Kosowsky
Journal: Mamm Genome Date: 1991 Impact factor: 2.957

Review 4. Genetic control and ontogeny of microbody enzymes: a review.

Authors: R S Holmes; C J Masters
Journal: Biochem Genet Date: 1978-04 Impact factor: 1.890

Review 5. Genetics of beta-2 microglobulin in the mouse.

Authors: J Michaelson
Journal: Immunogenetics Date: 1983 Impact factor: 2.846

6. Genetics of peroxisomal enzymes in the mouse: nonlinkage of D-amino acid oxidase locus (Dao) to catalase (Cs) and L-alpha-hydroxyacid oxidase (Hao-1) loci on chromosome 2.

Authors: R S Holmes
Journal: Biochem Genet Date: 1976-12 Impact factor: 1.890

7. Biochemical genetics of aldehyde dehydrogenase isozymes in the mouse: evidence for stomach- and testis-specific isozymes.

Authors: P B Mather; R S Holmes
Journal: Biochem Genet Date: 1984-12 Impact factor: 1.890

Alpha-hydroxyacid oxidase genetics in the mouse: evidence for two genetic loci and a tetrameric subunit structure for the liver isozyme.

1. Catalase multiplicity in normal and acatalasemic mice.

2. L-alpha-Hydroxy acid oxidases of hog renal cortex.

3. Molecular weight of mammalian L-amino-acid oxidase from rat kidney.

4. Aliphatic L-alpha-hydroxyacid oxidase from rat livers: purification and properties.

5. Mitochondrial malate dehydrogenase and malic enzyme: Mendelian inherited electrophoretic variants in the mouse.

6. Aliphatic L-alpha-hydroxyacid oxidase from rat liver. II. A flavoprotein.

7. Purification and characterization of glycolic acid oxidase from pig liver.

8. Human red cell peptidases.

9. Studies on the deamination of L-amino acids in mammalian tissues.