Literature DB >> 4817191

Alternatives to animal experiments in medical research.

J L Gowans.   

Abstract

In laboratory work which involves the large-scale routine assay of biologically-active substances the sponsors of "alternative" (in vitro) methods and the scientists have a common aim: a reduction in the use of living animals. In vitro methods are usually more accurate, easier to perform, and cheaper. Animals are no longer required for the production of certain antiviral vaccines.Those engaged in medical research where new knowledge is being sought also need no incentive to develop in vitro methods because they make refined analysis possible. Nevertheless, such in vitro methods are usually not alternatives in the sense that they substitute for animals; they complement experiments on animals. A legal requirement "that no experiment on a living animal may be performed if the purpose of the experiment can be achieved by alternative means not involving an experiment on a living animal" would be unenforceable.

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Year:  1974        PMID: 4817191      PMCID: PMC1633654          DOI: 10.1136/bmj.1.5907.557

Source DB:  PubMed          Journal:  Br Med J        ISSN: 0007-1447


  10 in total

1.  Induction fo B cell tolerance by antigen specific T cell factor.

Authors:  M Feldman
Journal:  Nat New Biol       Date:  1973-03-21

2.  Antibody in the induction and inhibition of lymphocyte cytotoxicity.

Authors:  I C MacLennan
Journal:  Transplant Rev       Date:  1972

3.  Lymphocyte mediated cytotoxicity in vitro. Induction and inhibition by humoral antibody and nature of effector cells.

Authors:  P Perlmann; H Perlmann; H Wigzell
Journal:  Transplant Rev       Date:  1972

4.  The role of lymphocytes in antibody formation. II. The influence of lymphocyte migration on the initiation of antibody formation in the isolated, perfused spleen.

Authors:  W L Ford; J L Gowans
Journal:  Proc R Soc Lond B Biol Sci       Date:  1967-09-12

5.  Immunologic approach to cancer.

Authors:  N A Mitchison
Journal:  Transplant Proc       Date:  1970-03       Impact factor: 1.066

6.  Immunization of mice against Ehrlich ascites tumour using a hamster-Ehrlich ascites tumour hybrid cell line.

Authors:  J F Watkins; L Chen
Journal:  Nature       Date:  1969-09-06       Impact factor: 49.962

Review 7.  Immunological enhancement as studied by cell culture techniques.

Authors:  K E Hellström; I Hellström
Journal:  Annu Rev Microbiol       Date:  1970       Impact factor: 15.500

8.  Specific in vitro cytotoxicity of thymus-derived lymphocytes sensitized to alloantigens.

Authors:  J C Cerottini; A A Nordin; K T Brunner
Journal:  Nature       Date:  1970-12-26       Impact factor: 49.962

9.  Role of macrophages in tumour immunity. II. Involvement of a macrophage cytophilic factor during syngeneic tumour growth inhibition.

Authors:  R Evans; P Alexander
Journal:  Immunology       Date:  1972-10       Impact factor: 7.397

10.  Immunization of dissociated spleen cell cultures from normal mice.

Authors:  R I Mishell; R W Dutton
Journal:  J Exp Med       Date:  1967-09-01       Impact factor: 14.307

  10 in total

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