Literature DB >> 4816301

The K-chains of the immunoglobulin from a continuous culture of human lymphocytes (Daudi) have an unusual molecular size.

S J Kennel.   

Abstract

Membrane-associated immunoglobulin (M-Ig) was isolated from Daudi cells which had been radioiodinated using lactoperoxidase. This M-Ig was found to have a molecular size on SDS-PAGE of 330,000 daltons. The component protein chains (micro and K) have molecular sizes of 75,000 and 33,000 daltons, respectively. Further studies showed that [(3)H]galactose can be incorporated into K-chains, but that extra protein and not carbohydrate was responsible for the increased molecular size of this molecule.

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Year:  1974        PMID： 4816301      PMCID： PMC2139566          DOI： 10.1084/jem.139.4.1031

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  10 in total

1.  Isolation and characterization of plasma membrane associated immunoglobulin from cultured human diploid lymphocytes.

Authors:  S J Kennel; R A Lerner
Journal:  J Mol Biol       Date:  1973-06-05       Impact factor: 5.469

2.  Human erythrocyte membrane glycoprotein: a re-evaluation of the molecular weight as determined by SDS polyacrylamide gel electrophoresis.

Authors:  J P Segrest; R L Jackson; E P Andrews; V T Marchesi
Journal:  Biochem Biophys Res Commun       Date:  1971-07-16       Impact factor: 3.575

3.  Surface IgM-kappa specificity on a Burkitt lymphoma cell in vivo and in derived culture lines.

Authors:  E Klein; G Klein; J S Nadkarni; J J Nadkarni; H Wigzell; P Clifford
Journal:  Cancer Res       Date:  1968-07       Impact factor: 12.701

4.  A possible precursor of immunoglobulin light chains.

Authors:  C Milstein; G G Brownlee; T M Harrison; M B Mathews
Journal:  Nat New Biol       Date:  1972-09-27

5.  Complement receptors on cell membranes. I. Evidence for two complement receptors.

Authors:  H Okada; K Nishioka
Journal:  J Immunol       Date:  1973-11       Impact factor: 5.422

6.  Cell surface immunoglobulin. 3. Isolation and characterization of immunoglobulin from nonsecretory human lymphoid cells.

Authors:  C J Sherr; S Baur; I Grundke; J Zeligs; B Zeligs; J W Uhr
Journal:  J Exp Med       Date:  1972-06-01       Impact factor: 14.307

7.  Isolation of 7S IgM and kappa chains from the surface membrane of tissue culture cells derived from a Burkitt lymphoma.

Authors:  T Eskeland; E Klein
Journal:  J Immunol       Date:  1971-11       Impact factor: 5.422

8.  Absence of detectable IgM in enzymatically or biosynthetically labeled thymus-derived lymphocytes.

Authors:  B Lisowska-Bernstein; A Rinuy; P Vassalli
Journal:  Proc Natl Acad Sci U S A       Date:  1973-10       Impact factor: 11.205

9.  Immunoglobulin synthesis and secretion. VI. Synthesis and intracellular transport of immunoglobulin in nonsecretory lymphoma cells.

Authors:  C J Sherr; J W Uhr
Journal:  J Exp Med       Date:  1971-04-01       Impact factor: 14.307

10.  Cell surface immunoglobulin. II. Isolation and characterization of immunoglobulin from mouse splenic lymphocytes.

Authors:  E S Vitetta; S Baur; J W Uhr
Journal:  J Exp Med       Date:  1971-07-01       Impact factor: 14.307
  10 in total

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