Literature DB >> 4813214

Characterization of rat liver subcellular membranes. Demonstration of membrane-specific autoantigens.

D H DeHeer, M S Olson, R N Pinckard.   

Abstract

The induction of acute hepatocellular necrosis in rats resulted in the production of complement fixing, IgM autoantibodies directed toward inner and outer mitochondrial membranes, microsomal membrane, lysosomal membrane, nuclear membrane, cytosol, but not to plasma membrane. Utilizing selective absorption procedures it was demonstrated that each subcellular membrane fraction possessed unique autoantigenic activity with little or no cross-reactivity between the various membrane fractions. It is proposed that the development of membrane-specific autoantibodies may provide an immunological marker useful in the differential characterization of various subcellular membranes.

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Year:  1974        PMID： 4813214      PMCID： PMC2109171          DOI： 10.1083/jcb.60.2.460

Source DB:  PubMed          Journal:  J Cell Biol        ISSN： 0021-9525            Impact factor:   10.539


  37 in total

1.  LIVER AUTOANTIBODIES IN THE RAT.

Authors:  D M WEIR
Journal:  Immunology       Date:  1963-11       Impact factor: 7.397

2.  Distribution of enzymes between subcellular fractions in animal tissues.

Authors:  C DE DUVE; R WATTIAUX; P BAUDHUIN
Journal:  Adv Enzymol Relat Subj Biochem       Date:  1962

3.  Preparation and characterization of golgi membranes from rat liver.

Authors:  B Fleischer; S Fleischer
Journal:  Biochim Biophys Acta       Date:  1970-12-01

4.  A modified method for the isolation of the plasma membrane from rat liver.

Authors:  T K Ray
Journal:  Biochim Biophys Acta       Date:  1970-01-06

5.  Studies on plasma membranes. 3. Mg2+-ATPase,(Na+-K+-Mg2+)-ATPase and 5'-nucleotidase activity of plasma membranes isolated from rat liver.

Authors:  P Emmelot; C J Bos
Journal:  Biochim Biophys Acta       Date:  1966-07-13

6.  The composition of phospholipids in outer and inner mitochondrial membranes from guinea-pig liver.

Authors:  J G Parkes; W Thompson
Journal:  Biochim Biophys Acta       Date:  1970

7.  Studies on plasma membranes. XVI. Tissue specific antigens in the liver cell surface.

Authors:  J B Sheffield; P Emmelot
Journal:  Exp Cell Res       Date:  1972-03       Impact factor: 3.905

8.  Characteristics of isolated and purified preparations of the outer and inner membranes of mitochondria.

Authors:  D F Parsons; G R Williams; B Chance
Journal:  Ann N Y Acad Sci       Date:  1966-07-14       Impact factor: 5.691

9.  Comparison of rat liver mitochondrial and microsomal membrane proteins.

Authors:  C A Schnaitman
Journal:  Proc Natl Acad Sci U S A       Date:  1969-06       Impact factor: 11.205

10.  Dimethylnitrosamine-induced hepatic cirrhosis: a new canine model of an ancient human disease.

Authors:  J W Madden; P M Gertman; E E Peacock
Journal:  Surgery       Date:  1970-07       Impact factor: 3.982
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  3 in total

1.  A diagnostic marker of autoimmune chronic active hepatitis: liver plasma membrane antibody in the serum absorbed with particulate fraction of kidney homogenate.

Authors:  G Toda; Y Ikeda; N Hashimoto; T Maruyama; H Oka
Journal:  Gastroenterol Jpn       Date:  1987-06

2.  Human monoclonal antibody recognizing liver-type aldolase B.

Authors:  N Hibi; S Arii; T Iizumi; T Nemoto; T M Chu
Journal:  Biochem J       Date:  1986-12-15       Impact factor: 3.857

3.  Immunochemical characterization of synaptosomal membrane antigens from chicken brain : Histochemical localization in the day-old chick.

Authors:  J A Rostas; P L Jeffrey
Journal:  Neurochem Res       Date:  1977-02       Impact factor: 3.996
  3 in total

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