Literature DB >> 4812038

Radioreceptor assay for 1 alpha,25-dihydroxyvitamin D3.

P F Brumbaugh, D H Haussler, R Bressler, M R Haussler.   

Abstract

A competitive protein binding assay with a sensitivity of 80 picograms has been developed for 1alpha,25-dihydroxyvitamin D(3), the hormonal form of vitamin D(3). lalpha,25-Dihydroxyvitamin D(3) displaced tritiated hormone from a cytosol-chromatin receptor preparation isolated from chick small intestine, providing a simple assay for the hormone. The concentration of lalpha, 25-dihydroxyvitamin D(3) in human plasma, as determined by this assay, is approximately 6 nanograms per 100 milliliters; in patients with renal disease the concentration of this kidney-produced hormone is significantly lower.

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Year:  1974        PMID： 4812038     DOI： 10.1126/science.183.4129.1089

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  28 in total

1.  Dissociation of renal cyclic AMP and phosphate responses to parathyroid hormone in uremia.

Authors:  J E Russell; M Kleerekoper; E Slatopolsky; J Lewis; S W Lee; L V Avioli
Journal:  Calcif Tissue Int       Date:  1979-11-26       Impact factor: 4.333

2.  The assessment of circulating 25(OH)D and 1,25(OH)2D: where we are and where we are going.

Authors:  Bruce W Hollis; Ronald L Horst
Journal:  J Steroid Biochem Mol Biol       Date:  2007-01-02       Impact factor: 4.292

3.  The role of 1 alpha, 25-dihydroxyvitamin D in the mediation of intestinal hyperabsorption of calcium in primary hyperparathyroidism and absorptive hypercalciuria.

Authors:  R A Kaplan; M R Haussler; L J Deftos; H Bone; C Y Pak
Journal:  J Clin Invest       Date:  1977-05       Impact factor: 14.808

4.  Profile of David Haussler.

Authors:  Philip Downey
Journal:  Proc Natl Acad Sci U S A       Date:  2008-09-17       Impact factor: 11.205

5.  1,25-Dihydroxyvitamin D3: mode of action in intestine and parathyroid glands, assay in humans and isolation of its glycoside from Solanum malacoxylon.

Authors:  M R Haussler; M R Hughes; T A McCain; J E Zerwekh; P F Brumbaugh; W Jubiz; R H Wasserman
Journal:  Calcif Tissue Res       Date:  1977-05

6.  [Immunoreactive parathyroid hormone, 25-hydroxycalciferol and bone histology in renal osteodystrophy (author's transl)].

Authors:  G Offermann; K Schaefer; A Schulz; G Delling
Journal:  Klin Wochenschr       Date:  1976-07-01

7.  Magnesium absorption in the human small intestine. Results in normal subjects, patients with chronic renal disease, and patients with absorptive hypercalciuria.

Authors:  P G Brannan; P Vergne-Marini; C Y Pak; A R Hull; J S Fordtran
Journal:  J Clin Invest       Date:  1976-06       Impact factor: 14.808

8.  Jejunal and ileal adaptation to alterations in dietary calcium: changes in calcium and magnesium absorption and pathogenetic role of parathyroid hormone and 1,25-dihydroxyvitamin D.

Authors:  D A Norman; J S Fordtran; L J Brinkley; J E Zerwekh; M J Nicar; S M Strowig; C Y Pak
Journal:  J Clin Invest       Date:  1981-06       Impact factor: 14.808

9.  Do tissues other than the kidney produce 1,25-dihydroxyvitamin D3 in vivo? A reexamination.

Authors:  T D Shultz; J Fox; H Heath; R Kumar
Journal:  Proc Natl Acad Sci U S A       Date:  1983-03       Impact factor: 11.205

10.  Inhibition of parathyroid hormone secretion by 25-hydroxycholecalciferol and 24,25-dihydroxycholecalciferol in the dog.

Authors:  J M Canterbury; S Lerman; A J Claflin; H Henry; A Norman; E Reiss
Journal:  J Clin Invest       Date:  1978-05       Impact factor: 14.808
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