Literature DB >> 4812036

Arachidonic acid causes sudden death in rabbits.

M J Silver, W Hoch, J J Kocsis, C M Ingerman, J B Smith.   

Abstract

Injection of sodium arachidonate (1.4 milligrams per kilogram) into the marginal ear veins of rabbits caused death within 3 minutes. Histological examination showed platelet thrombi in the microvasculature of the lungs. Rabbits were protected from the lethal effects of arachidonic acid by pretreatment with aspirin. Fatty acids closely related to arachidonic acid did not cause death.

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Year:  1974        PMID： 4812036     DOI： 10.1126/science.183.4129.1085

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  25 in total

Review 1.  Immediate and long range effects of the uptake of increased amounts of arachidonic acid.

Authors:  O Adam
Journal:  Clin Investig       Date:  1992-09

2.  The effect of short-term diets rich in fish, red meat, or white meat on thromboxane and prostacyclin synthesis in humans.

Authors:  N Mann; A Sinclair; M Pille; L Johnson; G Warrick; E Reder; R Lorenz
Journal:  Lipids       Date:  1997-06       Impact factor: 1.880

3.  Pulmonary microembolism by platelet aggregates as a cause of unexpected sudden death.

Authors:  H Pirkle
Journal:  West J Med       Date:  1975-12

4.  Inhibition of arachidonic acid induced mortality in rabbits with several non-steroidal anti-inflammatory agents.

Authors:  G DiPasquale; D Mellace
Journal:  Agents Actions       Date:  1977-10

5.  Blood platelets and the inflammatory process.

Authors:  M J Silver; J B Smith; C M Ingerman
Journal:  Agents Actions       Date:  1974-10

6.  Provocation of pulmonary vascular endothelial injury in rabbits by human recombinant interleukin-1 beta.

Authors:  S E Goldblum; K Yoneda; D A Cohen; C J McClain
Journal:  Infect Immun       Date:  1988-09       Impact factor: 3.441

7.  Neutrophil aggregation and degranulation. Effect of arachidonic acid.

Authors:  J T O'Flaherty; H J Showell; E L Becker; P A Ward
Journal:  Am J Pathol       Date:  1979-05       Impact factor: 4.307

8.  Anti-aggregatory effect of prostacyclin (PGI2) in vivo.

Authors:  B L Bayer; K E Blass; W Förster
Journal:  Br J Pharmacol       Date:  1979-05       Impact factor: 8.739

9.  Phorbol myristate acetate: in vivo effects upon neutrophils, platelets, and lung.

Authors:  J T O'Flaherty; S Cousart; A S Lineberger; E Bond; D A Bass; L R DeChatelet; E S Leake; C E McCall
Journal:  Am J Pathol       Date:  1980-10       Impact factor: 4.307

10.  Vasoconstrictor response to arachidonic acid in the isolated hind limb of the dog.

Authors:  T M Fitzpatrick; M Johnson; P A Kot; P W Ramwell; J C Rose
Journal:  Br J Pharmacol       Date:  1977-02       Impact factor: 8.739
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