Literature DB >> 479904

Spinal cord regeneration in rats made immunologically unresponsive to CNS antigens.

E R Feringa, K R Nelson, H L Vahlsing, R C Dauser.   

Abstract

Seventy days after complete spinal cord transection, both treated and untreated rats showed evidence that some corticospinal axons had regenerated. Rats made immunologically unresponsive to CNS tissue showed no increase in corticospinal regeneration as measured by orthograde axoplasmic flow of tritated proline or retrograde axoplasmic labelling with horeseradish peroxidase. However, treated rats did demonstrate electrophysiological evidence of regeneration of long ascending sensory pathways. Tolerant animals additionally treated with cyclophosphamide showed corticospinal axonal regeneration by tritated proline transport and electrophysiological techniques and also showed electrophysiological evidence of ascending sensory tract regeneration.

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Year:  1979        PMID： 479904      PMCID： PMC490279          DOI： 10.1136/jnnp.42.7.642

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  22 in total

1.  A tissue-culture approach to demyelinative disorders.

Authors:  M B BORNSTEIN
Journal:  Natl Cancer Inst Monogr       Date:  1963-03

2.  Antibody response to heterologous protein in rabbits of varying maturity.

Authors:  D V EITZMAN; R T SMITH
Journal:  Proc Soc Exp Biol Med       Date:  1959 Oct-Dec

3.  Studies of immunological tolerance to nervous tissue in rats.

Authors:  P Y PATERSON
Journal:  Ann N Y Acad Sci       Date:  1958-10-07       Impact factor: 5.691

4.  Studies of immunologic reactions after brain injury. II. Antibodies against brain tissue lipids after blunt head injury in man.

Authors:  M Procházka; M Voltnerová; J Stefan
Journal:  Int Surg       Date:  1971-05

5.  Experimental allergic encephalomyelitis: demyelinating activity of serum and sensitized lymph node cells on cultured nerve tissues.

Authors:  M B Bornstein; H Iwanami
Journal:  J Neuropathol Exp Neurol       Date:  1971-04       Impact factor: 3.685

6.  Studies of cyclophosphamide suppression of experimental allergic encephalomyelitis in Wistar rats.

Authors:  P Y Paterson; M A Hanson
Journal:  J Immunol       Date:  1969-10       Impact factor: 5.422

7.  Regeneration of corticospinal axons in the rat.

Authors:  E R Feringa; L M Shuer; H L Vahlsing; S W Davis
Journal:  Ann Neurol       Date:  1977-10       Impact factor: 10.422

8.  Studies on cell-mediated hypersensitivity to neural antigens after experimental spinal cord injury.

Authors:  D O Willenborg; E A Staten; E Eidelberg
Journal:  Exp Neurol       Date:  1977-02       Impact factor: 5.330

9.  Fink-Heimer/Nauta demonstration of regenerating axons in the rat spinal cord.

Authors:  E R Feringa; S W Davis; H L Vahlsing; L M Shuer
Journal:  Arch Neurol       Date:  1978-08

10.  Immunological unresponsiveness in rabbits produced by neonatal injection of defined antigens.

Authors:  R T SMITH; R A BRIDGES
Journal:  J Exp Med       Date:  1958-08-01       Impact factor: 14.307
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  2 in total

1.  Spinal cord grafts in oculo: survival, growth, histological organization and electrophysiological characteristics.

Authors:  A Henschen; B Hoffer; L Olson
Journal:  Exp Brain Res       Date:  1985       Impact factor: 1.972

2.  The orthograde flow of tritiated proline in corticospinal neurons at various ages and after spinal cord injury.

Authors:  E R Feringa; H L Vahlsing; R C Dauser
Journal:  J Neurol Neurosurg Psychiatry       Date:  1984-09       Impact factor: 10.154
  2 in total

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