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Literature DB >> 479872

Opposite effects of naloxone on substance P-induced changes in brain DOPA synthesis and in locomotor activity in rats.

J A Garcia-Sevilla, T Magnusson, A Carlsson.

Abstract

Intracerebroventricular injection of substance P (SP) enhanced the synthesis of dopamine and noradrenaline (measured as increase in DOPA formation after inhibition of the aromatic L-amino-acid decarboxylase) in rat brain. These biochemical effects were blocked in most brain regions by pretreatment with naloxone. SP also induced vasodilation, salivation and increased locomotor activity. These effects were not antagonized, but, in the case of locomotor activity, potentiated by naloxone. The data suggest the existence of specific SP-containing neuronal pathways for behavior, which pathways are not related to those regulating the synthesis of brain catecholamines.

Entities: Chemical Disease Species

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Year: 1979 PMID： 479872 DOI： 10.1007/bf01244407

Source DB: PubMed Journal: J Neural Transm Impact factor: 3.575

29 in total

1. Dual actions of substance P on nociception: possible role of endogenous opioids.

Authors: R C Frederickson; V Burgis; C E Harrell; J D Edwards
Journal: Science Date: 1978-03-24 Impact factor: 47.728

2. Localization of opiate receptors and enkephalins in the rat striatum in relationship with the nigrostriatal dopaminergic system: lesion studies.

Authors: H Pollard; C Llorens; J C Schwartz; C Gros; F Dray
Journal: Brain Res Date: 1978-08-04 Impact factor: 3.252

3. Substance p: localization in the central nervous system and in some primary sensory neurons.

Authors: T Hökfelt; J O Kellerth; G Nilsson; B Pernow
Journal: Science Date: 1975-11-28 Impact factor: 47.728

4. Effect of synthetic substance P on monoaminergic mechanisms in brain.

Authors: T Magnusson; A Carlsson; G H Fisher; D Chang; K Folkers
Journal: J Neural Transm Date: 1976 Impact factor: 3.575

5. Distribution of substance P-like immuno-reactivity in the rat central nervous system as revealed by immunohistochemistry.

Authors: G Nilsson; T Hökfelt; B Pernow
Journal: Med Biol Date: 1974-12

6. Radioimmunoassay for substance P.

Authors: D Powell; S Leeman; G W Tregear; H D Niall; J T Potts
Journal: Nat New Biol Date: 1973-02-21

7. A procedure for the isolation of noradrenaline (together with adrenaline), dopamine, 5-hydroxytryptamine and histamine from the same tissue sample using a single column of strongly acidic cation exchange resin.

Authors: C Atack; T Magnusson
Journal: Acta Pharmacol Toxicol (Copenh) Date: 1978-01

Opposite effects of naloxone on substance P-induced changes in brain DOPA synthesis and in locomotor activity in rats.

1. Dual actions of substance P on nociception: possible role of endogenous opioids.

2. Localization of opiate receptors and enkephalins in the rat striatum in relationship with the nigrostriatal dopaminergic system: lesion studies.

3. Substance p: localization in the central nervous system and in some primary sensory neurons.

4. Effect of synthetic substance P on monoaminergic mechanisms in brain.

5. Distribution of substance P-like immuno-reactivity in the rat central nervous system as revealed by immunohistochemistry.

6. Radioimmunoassay for substance P.

7. A procedure for the isolation of noradrenaline (together with adrenaline), dopamine, 5-hydroxytryptamine and histamine from the same tissue sample using a single column of strongly acidic cation exchange resin.

8. Effect of ethanol on the hydroxylation of tyrosine and tryptophan in rat brain in vivo.

9. Substance P release from the rat substantia nigra.

10. Substance P in the amygdaloid complex, bed nucleus and stria terminalis of the rat brain.

1. Behavioural effects of (-)naloxone in mice from four inbred strains.

2. Morphine differentially alters synthesis and turnover of dopamine in central neuronal systems.