Literature DB >> 4797167

Evidence for the binding of the carcinogen 3-methylcholanthrene to both the purine and the pyrimidine bases of hamster fibroblast deoxyribonucleic acid.

P A Jones, W Gevers, A O Hawtrey.   

Abstract

The binding of [(3)H]3-methylcholanthrene to the DNA of hamster fibroblasts was studied by using chemical methods for DNA degradation. DNA depurinated by mild acid hydrolysis released approximately half of the radioactivity at the same rate as the purine bases, but the resulting apurinic acid still contained radioactive carcinogen.

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Year:  1973        PMID： 4797167      PMCID： PMC1165833          DOI： 10.1042/bj1350375

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  12 in total

1.  Changes of nuclear RNA in hepatomas as revealed by RNA-DNA hybridization.

Authors:  V P Chiarugi
Journal:  Biochim Biophys Acta       Date:  1969-03-18

2.  Transformation of hamster cells in vitro by 1- -D arabinofuranosylcytosine, 5-fluorodeoxyuridine and hydroxyurea.

Authors:  P A Jones; J V Taderera; A O Hawtrey
Journal:  Eur J Cancer       Date:  1972-12       Impact factor: 9.162

Review 3.  Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.

Authors:  J A Miller
Journal:  Cancer Res       Date:  1970-03       Impact factor: 12.701

4.  Isolation and degradation of DNA from cells treated with tritium-labeled 7,12-dimethylbenz(a)anthracene: studies on the nature of the binding of this carcinogen to DNA.

Authors:  P Brookes; C Heidelberger
Journal:  Cancer Res       Date:  1969-01       Impact factor: 12.701

5.  The binding of polycyclic aromatic hydrocarbons to the DNA, RNA, and proteins of transformable cells in culture.

Authors:  T Kuroki; C Heidelberger
Journal:  Cancer Res       Date:  1971-12       Impact factor: 12.701

6.  Structure and activity in chemical carcinogenesis. Studies of variously substituted 7-bromomethylbenz(a)anthracenes.

Authors:  A Dipple; T A Slade
Journal:  Eur J Cancer       Date:  1971-10       Impact factor: 9.162

7.  A microsome-dependent binding of benzo[a]pyrene to DNA.

Authors:  H V Gelboin
Journal:  Cancer Res       Date:  1969-06       Impact factor: 12.701

8.  In vitro transformation of normal cells to tumor cells by carcinogenic hydrocarbons.

Authors:  Y Berwald; L Sachs
Journal:  J Natl Cancer Inst       Date:  1965-10       Impact factor: 13.506

9.  The formation apurinic acid from the desoxyribonucleic acid of calf thymus.

Authors:  C TAMM; M E HODES; E CHARGAFF
Journal:  J Biol Chem       Date:  1952-03       Impact factor: 5.486

10.  Plaque formation and isolation of pure lines with poliomyelitis viruses.

Authors:  R DULBECCO; M VOGT
Journal:  J Exp Med       Date:  1954-02       Impact factor: 14.307
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