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Literature DB >> 4795550

Hypothalamic obesity: the myth of the ventromedial nucleus.

Abstract

Lesions restricted to the ventromedial nucleus of the hypothalamus were neither necessary nor sufficient for, and did not contribute to, the production of hypothalamic obesity. Hypothalamic lesions and knife cuts that do produce obesity damage the nearby ventral noradrenergic bundle or its terminals.

Entities: Disease

Mesh：

Year: 1973 PMID： 4795550 DOI： 10.1126/science.182.4111.488

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

30 in total

1. Elevation of rat plasma insulin by intrathecal pentobarbital.

Authors: P J Kulkosky; D Porte; S C Woods
Journal: Experientia Date: 1975-01-15

2. Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus.

Authors: Ki Woo Kim; Liping Zhao; Jose Donato; Daisuke Kohno; Yong Xu; Carol F Elias; Charlotte Lee; Keith L Parker; Joel K Elmquist
Journal: Proc Natl Acad Sci U S A Date: 2011-06-02 Impact factor: 11.205

Review 3. Hypothalamic substrates of metabolic imprinting.

Authors: Richard B Simerly
Journal: Physiol Behav Date: 2007-11-22

4. Effects of lesions of the ventromedial hypothalamus on naloxone-induced morphine withdrawal in rats.

Authors: M A Linseman
Journal: Psychopharmacologia Date: 1976-02-02

5. PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis.

Authors: Yong Xu; Jennifer W Hill; Makoto Fukuda; Laurent Gautron; Jong-Woo Sohn; Ki-Woo Kim; Charlotte E Lee; Michelle J Choi; Danielle A Lauzon; Harveen Dhillon; Bradford B Lowell; Jeffrey M Zigman; Jean J Zhao; Joel K Elmquist
Journal: Cell Metab Date: 2010-07-07 Impact factor: 27.287

Hypothalamic obesity: the myth of the ventromedial nucleus.

1. Elevation of rat plasma insulin by intrathecal pentobarbital.

2. Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus.

Review 3. Hypothalamic substrates of metabolic imprinting.

4. Effects of lesions of the ventromedial hypothalamus on naloxone-induced morphine withdrawal in rats.

5. PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis.

Review 6. The central nervous system sites mediating the orexigenic actions of ghrelin.

Review 7. The neuropathology of obesity: insights from human disease.

8. CNS modulation of pancreatic endocrine function : Multiple modes of expression.

9. The role of hyperinsulinema and the vagus nerve in hypothalamic hyperphagia reexamined.

Review 10. Sweet talk in the brain: glucosensing, neural networks, and hypoglycemic counterregulation.