Literature DB >> 4794

A 15-hydroxyprostaglandin dehydrogenase specific for prostaglandin A in rabbit kidney.

H G Oien, E A Ham, M E Zanetti, E H Ulm, F A Kuehl.   

Abstract

Examination of a soluble fraction derived from homogenates of rabbit kidney papilla revealed the existence of a 15-hydroxyprostaglandin dehydrogenase specific for A-type prostaglandins. Prostaglandins of the E- and F-series were not substrates for this enzyme. In agreement with published data, the 15-hydroxyprostaglandin dehydrogenase(s) derived from the kidney cortex were found to degrade all prostaglandins examined (PGE, PGF, PGA) in the presence of added cofactor NAD. Thus it is evident that in this species the kidney 15-hydroxyprostaglandin dehydrogenases are anatomically compartmentalized so that the papilla is able to metabpable of degrading E-, F-, and A-type prostaglandins by this metabolic pathway.

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Year:  1976        PMID： 4794      PMCID： PMC430209          DOI： 10.1073/pnas.73.4.1107

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  15 in total

1.  Metabolism of prostaglandin A. I. The kidney cortex as a major site of PGA2 degradation.

Authors:  A A Attallah; W Payakkapan; J B Lee
Journal:  Life Sci       Date:  1974-04-16       Impact factor: 5.037

2.  Purification of 15-hydroxy prostaglandin dehydrogenase from bovine lung.

Authors:  S A Saeed; A C Roy
Journal:  Biochem Biophys Res Commun       Date:  1972-04-14       Impact factor: 3.575

3.  Preparative thin-layer and column chromatography of prostaglandins.

Authors:  N H Anders
Journal:  J Lipid Res       Date:  1969-05       Impact factor: 5.922

4.  Regional differences in the formation and metabolism of prostaglandins in the rabbit kidney.

Authors:  C Larsson; E Anggård
Journal:  Eur J Pharmacol       Date:  1973-01       Impact factor: 4.432

5.  15-Hydroxy-prostanoate dehydrogenase. Prostaglandins as substrates and inhibitors.

Authors:  J Nakano; E Anggård; B Samuelsson
Journal:  Eur J Biochem       Date:  1969-12

6.  The action of prostaglandin 15-hydroxydehydrogenase on various prostaglandins.

Authors:  H Vonkeman; D H Nugteren; D A van Dorp
Journal:  Biochim Biophys Acta       Date:  1969-12-17

7.  An improved procedure for the enzymatic analysis of prostaglandins in the nanogram range.

Authors:  F M Matschinsky; D Shanahan; J Ellerman
Journal:  Anal Biochem       Date:  1974-07       Impact factor: 3.365

8.  Prostaglandin metabolism. II. Identification of two 15-hydroxyprostaglandin dehydrogenase types.

Authors:  S C Lee; L Levine
Journal:  J Biol Chem       Date:  1975-01-25       Impact factor: 5.157

9.  Interaction of prostaglandins with blood plasma proteins. Comparative binding of prostaglandins A 2 , F 2 and E 2 to human plasma proteins.

Authors:  A Raz
Journal:  Biochem J       Date:  1972-11       Impact factor: 3.857

10.  Prostaglandins A1,A2 and 19-hydroxy A1; their actions on smooth muscle and their inactivation on passage through the pulmonary and hepatic portal vascular beds.

Authors:  E W Horton; R L Jones
Journal:  Br J Pharmacol       Date:  1969-11       Impact factor: 8.739
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  1 in total

1.  Testing the vesicular morphology to destruction: birth and death of diblock copolymer vesicles prepared via polymerization-induced self-assembly.

Authors:  Nicholas J Warren; Oleksandr O Mykhaylyk; Anthony J Ryan; Mark Williams; Tristan Doussineau; Philippe Dugourd; Rodolphe Antoine; Giuseppe Portale; Steven P Armes
Journal:  J Am Chem Soc       Date:  2015-01-27       Impact factor: 15.419
  1 in total

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