Literature DB >> 4790552

Cephamycins, a new family of beta-lactam antibiotics. I. Production by actinomycetes, including Streptomyces lactamdurans sp. n.

E O Stapley, M Jackson, S Hernandez, S B Zimmerman, S A Currie, S Mochales, J M Mata, H B Woodruff, D Hendlin.   

Abstract

A number of actinomycetes isolated from soil were found to produce one or more members of a new family of antibiotics, the cephamycins, which are structurally related to cephalosporin C. The cephamycins were produced in submerged fermentation in a wide variety of media by one or more of eight different species of Streptomyces, including a newly described species, S. lactamdurans. These antibiotics exhibit antibacterial activity against a broad spectrum of bacteria which includes many that are resistant to the cephalosporins and penicillins.

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Year:  1972        PMID： 4790552      PMCID： PMC444278          DOI： 10.1128/AAC.2.3.122

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  7 in total

1.  MICROBIAL DEGRADATION OF CEPHALOSPORIN C.

Authors:  A L DEMAIN; R B WALTON; J F NEWKIRK; I M MILLER
Journal:  Nature       Date:  1963-08-31       Impact factor: 49.962

2.  Cross-resistance studies and antibiotic identification.

Authors:  E O STAPLEY
Journal:  Appl Microbiol       Date:  1958-11

3.  A guide for the classification of streptomycetes according to selected groups; placement of strains in morphological sections.

Authors:  T G PRIDHAM; C W HESSELTINE; R G BENEDICT
Journal:  Appl Microbiol       Date:  1958-01

4.  The Utilization of Carbon Compounds by Some Actinomycetales as an Aid for Species Determination.

Authors:  T G Pridham; D Gottlieb
Journal:  J Bacteriol       Date:  1948-07       Impact factor: 3.490

5.  BACTERIAL PROTOPLASTS INDUCED BY PENICILLIN.

Authors:  J Lederberg
Journal:  Proc Natl Acad Sci U S A       Date:  1956-09       Impact factor: 11.205

6.  Cephamycins, a new family of beta-lactam antibiotics. II. Isolation and chemical characterization.

Authors:  T W Miller; R T Goegelman; R G Weston; I Putter; F J Wolf
Journal:  Antimicrob Agents Chemother       Date:  1972-09       Impact factor: 5.191

7.  Beta-lactam antibiotics from Streptomyces.

Authors:  R Nagarajan; L D Boeck; M Gorman; R L Hamill; C E Higgens; M M Hoehn; W M Stark; J G Whitney
Journal:  J Am Chem Soc       Date:  1971-05-05       Impact factor: 15.419
  7 in total
  36 in total

Review 1.  Discovery and development of new antimicrobial agents.

Authors:  T D Gootz
Journal:  Clin Microbiol Rev       Date:  1990-01       Impact factor: 26.132

2.  Efficient Transformation of the Cephamycin C Producer Nocardia lactamdurans and Development of Shuttle and Promoter-Probe Cloning Vectors.

Authors:  C V Kumar; J J Coque; J F Martín
Journal:  Appl Environ Microbiol       Date:  1994-11       Impact factor: 4.792

3.  Antibacterial activity of selected beta-lactam and aminoglycoside antibiotics against cephalothin-resistant Enterobacteriaceae.

Authors:  R P Lewis; R D Meyer; L L Kraus
Journal:  Antimicrob Agents Chemother       Date:  1976-05       Impact factor: 5.191

Review 4.  Genetics of antibiotic production.

Authors:  D A Hopwood; M J Merrick
Journal:  Bacteriol Rev       Date:  1977-09

5.  Sporulation and the production of serine protease and cephamycin C by Streptomyces lactamdurans.

Authors:  C L Ginther
Journal:  Antimicrob Agents Chemother       Date:  1979-04       Impact factor: 5.191

Review 6.  Interaction of penicillin with the bacterial cell: penicillin-binding proteins and penicillin-sensitive enzymes.

Authors:  P M Blumberg; J L Strominger
Journal:  Bacteriol Rev       Date:  1974-09

Review 7.  Newer beta-lactam antibiotics.

Authors:  J M Hamilton-Miller; W Brumfitt
Journal:  Infection       Date:  1974       Impact factor: 3.553

8.  Cephamycins, a new family of beta-lactam antibiotics. IV. In vivo studies.

Authors:  A K Miller; E Celozzi; Y Kong; B A Pelak; H Kropp; E O Stapley; D Hendlin
Journal:  Antimicrob Agents Chemother       Date:  1972-10       Impact factor: 5.191

9.  Cephamycins, a new family of beta-lactam antibiotics. 3. In vitro studies.

Authors:  A K Miller; E Celozzi; B A Pelak; E O Stapley; D Hendlin
Journal:  Antimicrob Agents Chemother       Date:  1972-10       Impact factor: 5.191

10.  Cloning and characterization of the isopenicillin N synthase gene of Streptomyces griseus NRRL 3851 and studies of expression and complementation of the cephamycin pathway in Streptomyces clavuligerus.

Authors:  M García-Domínguez; P Liras; J F Martín
Journal:  Antimicrob Agents Chemother       Date:  1991-01       Impact factor: 5.191
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