Literature DB >> 4788209

Predictions of the antimalarial activity of arylamidinoureas.

P J Goodford, F E Norrington, W H Richards, L P Walls.   

Abstract

1. Regression equations were calculated relating the observed antimalarial potencies of arylamidinoureas to their predicted physicochemical properties.2. A two-parameter equation was used to forecast the antimalarial activity of more arylamidinoureas.3. Thirteen compounds of the predicted type were synthesized, and their observed antimalarial potencies compared with the forecasts.

Entities:  

Mesh：

Substances：

Year:  1973        PMID： 4788209      PMCID： PMC1776147          DOI： 10.1111/j.1476-5381.1973.tb08253.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  1 in total

Review 1.  Prediction of pharmacological activity by the method of physicochemical-activity relationships.

Authors:  P J Goodford
Journal:  Adv Pharmacol Chemother       Date:  1973
  1 in total
  2 in total

1.  Forecasting the antimalarial activities of arylamidinoureas from their measured physicochemical properties.

Authors:  D Gilbert; P J Goodford; F E Norrington; B C Weatherley; S G Williams
Journal:  Br J Pharmacol       Date:  1975-09       Impact factor: 8.739

2.  The selection of arylamidinourea antimalarials by their predicted physicochemical properties.

Authors:  R Cranfield; P J Goodford; F E Norrington; W H Richards; G C Sheppey; S G Williams
Journal:  Br J Pharmacol       Date:  1974-09       Impact factor: 8.739
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.