Literature DB >> 4788042

Inhibition of noradrenaline release by lysergic acid diethylamide.

J Hughes.   

Abstract

Lysergic acid diethylamide (LSD) inhibits the release of labelled noradrenaline from the guinea-pig vas deferens during intramural nerve stimulation and causes a corresponding reduction in the contractions of the smooth muscle. These effects of LSD are most prominent at low stimulus frequencies and they are prevented by treatment with phentolamine. It is concluded that LSD inhibits noradrenaline release by interacting with presynaptic alpha-adrenoceptors.

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Year:  1973        PMID： 4788042      PMCID： PMC1776607          DOI： 10.1111/j.1476-5381.1973.tb08549.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  11 in total

1.  Influence of extracellular noradrenaline on the stimulation-evoked secretion of noradrenaline from sympathetic nerves: evidence for an -receptor-mediated feed-back inhibition of noradrenaline release.

Authors:  K Starke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1972       Impact factor: 3.000

2.  Unexplained inhibitory action of D-lysergic acid diethylamide (LSD) on postganglionic motor transmission in the guinea-pig vas deferens.

Authors:  N Ambache; L P Dunk; P Miall; M A Zar
Journal:  Br J Pharmacol       Date:  1971-08       Impact factor: 8.739

3.  3 H-noradrenaline release and mechanical response in the field stimulated mouse vas deferens.

Authors:  L O Farnebo; T Malamfors
Journal:  Acta Physiol Scand Suppl       Date:  1971

4.  Variations in noradrenaline output with respect to stimulus frequency, train length and origin of the transmitter.

Authors:  J Hughes; R H Roth
Journal:  Br J Pharmacol       Date:  1972-05       Impact factor: 8.739

5.  The effects of adrenaline, noradrenaline and isoprenaline on inhibitory alpha- and beta-adrenoceptors in the longitudinal muscle of the guinea-pig ileum.

Authors:  H W Kosterlitz; R J Lydon; A J Watt
Journal:  Br J Pharmacol       Date:  1970-06       Impact factor: 8.739

6.  An inhibition of post-ganglionic motor transmission in the mammalian vas deferens by D-lysergic acid diethylamide.

Authors:  N Ambache; L P Dunk; J Verney; M A Zar
Journal:  J Physiol       Date:  1973-06       Impact factor: 5.182

7.  Acceleration of noradrenaline biosynthesis in the guinea-pig vas deferens by potassium.

Authors:  M C Boadle-Biber; J Hughes; R H Roth
Journal:  Br J Pharmacol       Date:  1970-12       Impact factor: 8.739

8.  Antagonism of 5-hydroxytryptamine by LSD 25 in the central nervous system: a possible neuronal basis for the actions of LSD 25.

Authors:  R J Boakes; P B Bradley; I Briggs; A Dray
Journal:  Br J Pharmacol       Date:  1970-10       Impact factor: 8.739

9.  Evaluation of mechanisms controlling the release and inactivation of the adrenergic transmitter in the rabbit portal vein and vas deferens.

Authors:  J Hughes
Journal:  Br J Pharmacol       Date:  1972-03       Impact factor: 8.739

10.  Evidence for a central 5-hydroxytryptamine receptor stimulation by lysergic acid diethylamide.

Authors:  N E Andén; H Corrodi; K Fuxe; T Hökfelt
Journal:  Br J Pharmacol       Date:  1968-09       Impact factor: 8.739
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  13 in total

1.  The effects of lysergic acid diethylamide on the response to field stimulation of the rat vas deferens and the rat and cat anococcygeus muscles.

Authors:  J S Gillespie; J C McGrath
Journal:  Br J Pharmacol       Date:  1975-08       Impact factor: 8.739

2.  Effects of lysergic acid diethylamide on autonomic post-ganglionic transmission.

Authors:  N Ambache; S W Killick; V Srinivasan; M A Zar
Journal:  J Physiol       Date:  1975-04       Impact factor: 5.182

3.  Relative pre- and postsynaptic potencies of alpha-adrenoceptor agonists in the rabbit pulmonary artery.

Authors:  K Starke; T Endo; H D Taube
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1975       Impact factor: 3.000

4.  Evidence to support the hypothesis that ATP is a co-transmitter in rat vas deferens.

Authors:  A M French; N C Scott
Journal:  Experientia       Date:  1983-03-15

5.  Comparison of the effects of clonidine on pre- and postsynaptic adrenoceptors in the rabbit pulmonary artery. Alpha-sympathomimetic inhibition of Neurogenic vasoconstriction.

Authors:  K Starke; H Montel; W Gayk; R Merker
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1974       Impact factor: 3.000

6.  An analysis of the anatomical basis for the mechanical response to motor nerve stimulation of the rat vas deferens.

Authors:  P G Anton; M E Duncan; J C McGrath
Journal:  J Physiol       Date:  1977-12       Impact factor: 5.182

7.  Effect of morphine on adrenergic transmission in the mouse vas deferens. Assessment of agonist and antogonist potencies of narcotic analgesics.

Authors:  J Hughes; H W Kosterlitz; F M Leslie
Journal:  Br J Pharmacol       Date:  1975-03       Impact factor: 8.739

8.  Adrenergic and 'non-adrenergic' components in the contractile response of the vas deferens to a single indirect stimulus.

Authors:  J C McGrath
Journal:  J Physiol       Date:  1978-10       Impact factor: 5.182

9.  Release of [3H-noradrenaline from the motor adrenergic nerves of the anococcygeus muscle by lysergic acid diethylamide, tyramine or nerve stimulation.

Authors:  J C McGrath; H J Olverman
Journal:  Br J Pharmacol       Date:  1978-12       Impact factor: 8.739

10.  The effects of morphine on the release of noradrenaline from the mouse vas deferens.

Authors:  G Henderson; J Hughes
Journal:  Br J Pharmacol       Date:  1976-08       Impact factor: 8.739
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