Literature DB >> 478568

Sensitivity of cultured rat hepatocytes to aflatoxin B1 and benzo(a)pyrene.

W I Schaeffer, A H Chuang, N Heintz, E Bresnick.   

Abstract

We have tested the sensitivity of a cloned rat hepatocyte line, RL-PR-C, to aflatoxin B1 and benzo(a)pyrene as a function of population-doubling level. The cells were much more sensitive to the cytotoxic action of these agents subsequent to 230 population doublings. This sensitivity corresponded to the enhanced inducibility of aryl hydrocarbon hydroxylase activity by 3-methylcholanthrene.

Entities:  

Mesh：

Substances：

Year:  1979        PMID： 478568     DOI： 10.1007/bf02618412

Source DB:  PubMed          Journal:  In Vitro        ISSN： 0073-5655


  9 in total

1.  A diploid rat liver cell culture. III. Characterization of the heteroploid morphological variants which develop with time in culture.

Authors:  W I Schaeffer; M D Polifka
Journal:  Exp Cell Res       Date:  1975-10-01       Impact factor: 3.905

2.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

3.  Relationship of aryl hydrocarbon hydroxylase activity to benzo(a)pyrene-metabolizing activity of cells in culture.

Authors:  L Diamond; W M Baird
Journal:  Cancer Lett       Date:  1977-09       Impact factor: 8.679

4.  Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. I. Assay and properties of induced enzyme.

Authors:  D W Nebert; H V Gelboin
Journal:  J Biol Chem       Date:  1968-12-10       Impact factor: 5.157

5.  Induction of benzpyrene-hydroxylase activity in fetal rat liver explants. I. Metabolism of 3-methylcholanthrene and differential effects of its derivatives on benzpyrene-hydroxylase activity.

Authors:  K Bürki; R A Seibert; E Bresnick
Journal:  Biochim Biophys Acta       Date:  1972-01-27

6.  A diploid rat liver cell culture. 1. Characterization and sensitivity to aflatoxin B1.

Authors:  J Bausher; W I Schaeffer
Journal:  In Vitro       Date:  1974 Jan-Feb

7.  A diploid rat liver cell culture. IV. Malignant transformation by aflatoxin B1.

Authors:  W I Schaeffer; N H Heintz
Journal:  In Vitro       Date:  1978-05

8.  The ontogeny of nuclear aryl hydrocarbon hydroxylase.

Authors:  J C Nunnink; A H Chuang; E Bresnick
Journal:  Chem Biol Interact       Date:  1978-09       Impact factor: 5.192

9.  Variation in aryl hydrocarbon (benzo(a)pyrene) hydroxylase activity in heteroploid and predominantly diploid rat liver cells in culture.

Authors:  J P Whitlock; H V Gelboin; H G Coon
Journal:  J Cell Biol       Date:  1976-07       Impact factor: 10.539
  9 in total
  2 in total

1.  Repeated establishment of diploid epithelial cell cultures from normal and partially hepatectomized rats.

Authors:  A S Herrinig; R Raychaudhuri; S P Kelley; P T Iype
Journal:  In Vitro       Date:  1983-07

Review 2.  The 4S binding protein acts as a trans-regulator of the polycyclic hydrocarbon-inducible cytochrome P450.

Authors:  E Bresnick; L I Siegel; W H Houser
Journal:  Cancer Metastasis Rev       Date:  1988-04       Impact factor: 9.264
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.