Literature DB >> 478162

Domperidone in the treatment of dyspepsia: a double-blind placebo-controlled study.

E Arts, H Anthoni, G de Roy, J D'Hollander, H Verhaegen.   

Abstract

Domperidone, at a dosage of 20 mg t.d.s before meals, in a double-blind, crossover, placebo-controlled trial reduced the level of the symptoms of dyspepsia by 76% compared to a 16% reduction with placebo. This difference was statistically significant (p less than 0.001). Thirteen of the fourteen patients in the study preferred domperidone to placebo. Four patients in the active treatment period and one in the placebo complained of mild side-effects.

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Year:  1979        PMID: 478162     DOI: 10.1177/030006057900700208

Source DB:  PubMed          Journal:  J Int Med Res        ISSN: 0300-0605            Impact factor:   1.671


  5 in total

Review 1.  Domperidone, a new dopamine antagonist.

Authors:  M C Champion; M Hartnett; M Yen
Journal:  CMAJ       Date:  1986-09-01       Impact factor: 8.262

2.  Approach to dyspepsia.

Authors:  T Koppert; T J Elmslie
Journal:  Can Fam Physician       Date:  1988-03       Impact factor: 3.275

Review 3.  Functional dyspepsia. Current treatment recommendations.

Authors:  Gerald Holtmann; Nicholas J Talley
Journal:  Drugs       Date:  1993-06       Impact factor: 9.546

Review 4.  Domperidone. A review of its pharmacological activity, pharmacokinetics and therapeutic efficacy in the symptomatic treatment of chronic dyspepsia and as an antiemetic.

Authors:  R N Brogden; A A Carmine; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1982-11       Impact factor: 9.546

Review 5.  A therapeutic guide on pediatric irritable bowel syndrome and functional abdominal pain-not otherwise specified.

Authors:  Robyn Rexwinkel; Arine M Vlieger; Miguel Saps; Merit M Tabbers; Marc A Benninga
Journal:  Eur J Pediatr       Date:  2022-04-23       Impact factor: 3.860

  5 in total

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