Literature DB >> 477885

The 'mauve factor' of schizophrenia and porphyria, 5-hydroxyhaemopyrrole lactam, has low pharmacological potency on guinea-pig ileum.

A Gorchein, A T Rogers.   

Abstract

5-Hydroxyhaemopyrrole lactam, the 'mauve factor' reported in the urine of schizophrenics and porphyrics was found to inhibit electrically-stimulated contractions of guinea-pig ileum only at high concentrations (ID50 = 8.5 mM). This low potency makes it unlikely that the compound can account for neurotoxic effects in human porphyria.

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Year:  1979        PMID： 477885     DOI： 10.1007/bf01949952

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  15 in total

1.  The nonoccurrence of hemo- and kryptopyrrole in urine of schizophrenics.

Authors:  S J Jacobson; H Rapoport; G L Ellman
Journal:  Biol Psychiatry       Date:  1975-02       Impact factor: 13.382

2.  The response of the guineapig ileum to electrical stimulation by coaxial electrodes.

Authors:  W D PATON
Journal:  J Physiol       Date:  1955-02-28       Impact factor: 5.182

3.  Apparently non-indolic Ehrlich-positive substances related to mental illnesses.

Authors:  D G IRVINE
Journal:  J Neuropsychiatr       Date:  1961-08

4.  The effect of 4-ethyl-5-hydroxy-3,5-dimethyl-delta3-pyrrolin-2-one on haem metabolism in the rat [proceedings].

Authors:  D J Graham; G G Thompson; M R Moore; M J Brodie; A Goldberg
Journal:  Biochem Soc Trans       Date:  1977       Impact factor: 5.407

5.  Kryptopyrrole-like substance in acute intermittent porphyria.

Authors:  D G Irvine; L Wetterberg
Journal:  Lancet       Date:  1972-12-02       Impact factor: 79.321

6.  Experimental data to the pathogenesis of cryptopyrrole excretion in schizophrenia, I.

Authors:  I Huszák; I Durkó; K Karsai
Journal:  Acta Physiol Acad Sci Hung       Date:  1972

7.  Autotransfer chromatography in the characterization of pyrroles. Chemistry of multiple-spot phenomena.

Authors:  D G Irvine
Journal:  J Chromatogr       Date:  1976-07-21

8.  Hemopyrrole and kryptopyrrole are absent from the urine of schizophrenics and normal persons.

Authors:  P L Gendler; H A Duhan; H Rapoport
Journal:  Clin Chem       Date:  1978-02       Impact factor: 8.327

9.  Pharmacological properties of kryptopyrrole and its oxidation products on isolated sciatic nerve of rat and on guinea-pig ileum.

Authors:  A Gorchein; L D Mitchell; A T Rogers
Journal:  Br J Pharmacol       Date:  1979-01       Impact factor: 8.739

10.  The porphyrinogenic effects of kryptopyrrole in the rat and the occurrence of urinary kryptopyrrole in human hereditary hepatic porphyria.

Authors:  M J Brodie; D J Graham; G G Thompson; M R Moore; A Goldberg
Journal:  Clin Sci Mol Med       Date:  1976-05
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