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Literature DB >> 4778136

Temperature dependence of the ionic current kinetics of Myxicola giant axons.

Abstract

1. The temperature dependence of the sodium and potassium conductances of Myxicola giant axons was studied in the range of 1-18 degrees C.2. Analysis of voltage clamp records for step depolarizations of 20-150 mV yielded Q(10)'s for g(Na), g(K), and g(1) of 1.3-1.5. The steady-state parameters m(infinity) (v), n(infinity) (v) were independent of temperature. The time constants had Q(10)'s of: 2.64 +/- 0.2 for tau(m); 2.56 +/- 0.2 for tau(h); 3.02 +/- 0.3 for tau(n).3. tau(h) determined from the effects of prepulse duration rather than the decline in sodium current during a step depolarization had a Q(10) of 2.47 +/- 0.2.

Entities: Chemical

Mesh：

Substances：
Sodium
Potassium

Year: 1973 PMID： 4778136 PMCID： PMC1350739 DOI： 10.1113/jphysiol.1973.sp010384

Source DB: PubMed Journal: J Physiol ISSN： 0022-3751 Impact factor: 5.182

10 in total

25 in total

10. Axonal microtubules necessary for generation of sodium current in squid giant axons: I. Pharmacological study on sodium current and restoration of sodium current by microtubule proteins and 260K protein.

Authors: G Matsumoto; M Ichikawa; A Tasaki; H Murofushi; H Sakai
Journal: J Membr Biol Date: 1984 Impact factor: 1.843

Temperature dependence of the ionic current kinetics of Myxicola giant axons.

1. Ion movements during nerve activity.

2. A quantitative description of membrane current and its application to conduction and excitation in nerve.

3. Measurement of current-voltage relations in the membrane of the giant axon of Loligo.

Review 4. Conductance mechanisms in excitable cells.

5. Mechanism of negative temperature coefficient of nerve blocking action of allethrin.

6. The kinetics and rectifier properties of the slow potassium current in cardiac Purkinje fibres.

7. Effect of temperature and calcium ions on rate constants of myelinated nerve.

8. Inactivation of the sodium current in Myxicola giant axons. Evidence for coupling to the activation process.

9. Current- and voltage-clamped studies on Myxicola giant axons. Effect of tetrodotoxin.

10. Quantitative description of sodium and potassium currents and computed action potentials in Myxicola giant axons.

1. Comparison of two-pulse sodium inactivation with reactivation in Myxicola giant axons.

2. Electrostatic activation enthalpy for ion transport through a membrane channel.

3. Internal perfusion of the myxicola giant axon.

4. The effect of temperature on Na currents in rat myelinated nerve fibres.

5. Membrane currents of the tunicate egg under the voltage-clamp condition.

6. Characteristics of sodium tail currents in Myxicola axons. Comparison with membrane asymmetry currents.

7. A quantitative description of the sodium current in the rat sympathetic neurone.

8. Temperature experiments on nerve and muscle membranes of frogs. Indications for a phase transition.

9. Sodium and potassium fluxes across the dialyzed giant axon of Myxicola.

10. Axonal microtubules necessary for generation of sodium current in squid giant axons: I. Pharmacological study on sodium current and restoration of sodium current by microtubule proteins and 260K protein.