Literature DB >> 477734

Neurotensin contracts the guinea-pig longitudinal ileal smooth muscle by inducing acetylcholine release.

P Kitabgi, P Freychet.   

Abstract

Neurotensin contracted the isolated longitudinal smooth muscle strip of the guinea-pig ileum, but was only 22% as effective as histamine. Neostigmine (0.1 micrometer) increased the effectiveness of neurotensin 4-fold. Atropine (0.1 micrometer) completely inhibited the contracting effect of neurotensin measured in the presence of neostigmine, whereas hexamethonium (0.1 micrometer) was without effect. It is concluded that in the longitudinal smooth muscle of the guinea-pig ileum, the contracting effect of neurotensin is mediated by the release of acetylcholine from nerve endings in response to a postganglionic stimulation of cholinergic nerve fibers.

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Year:  1979        PMID： 477734     DOI： 10.1016/0014-2999(79)90272-3

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

1.  Effects of neurotensin on electrical and mechanical properties of smooth muscles in longitudinal and circular layers of the guinea-pig ileum.

Authors:  K Yamanaka; K Kitamura; H Kuriyama
Journal:  Pflugers Arch       Date:  1987-01       Impact factor: 3.657

2.  Effects of substance P, cholecystokinin octapeptide, bombesin, and neurotensin on the peristaltic reflex of the guinea-pig ileum in the absence and in the presence of atropine.

Authors:  L Barthó; P Holzer; J Donnerer; F Lembeck
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-12       Impact factor: 3.000

3.  Excitatory neurotensin receptors on the smooth muscle of the rat fundus: possible implications in gastric motility.

Authors:  J P Huidobro-Toro; A Kullak
Journal:  Br J Pharmacol       Date:  1985-04       Impact factor: 8.739

4.  Neuronal cholecystokinin, gastrin-releasing peptide, neurotensin, and beta-endorphin in the intestine of the guinea pig. Distribution and possible motor functions.

Authors:  S Leander; R Ekman; R Uddman; F Sundler; R Håkanson
Journal:  Cell Tissue Res       Date:  1984       Impact factor: 5.249

5.  Functional and neurochemical evidence that neurotensin-induced release of acetylcholine from Auerbach's plexus of guinea-pig ileum is presynaptically controlled via alpha 2-adrenoceptors.

Authors:  A D Rakovska
Journal:  Neurochem Res       Date:  1993-07       Impact factor: 3.996

6.  Membrane potential and current responses to neurotensin in the longitudinal muscle of the rectum of the fowl.

Authors:  S Komori; T Matsuoka; S C Kwon; T Takewaki; H Ohashi
Journal:  Br J Pharmacol       Date:  1992-11       Impact factor: 8.739

7.  Release of gamma-aminobutyric acid and acetylcholine by neurotensin in guinea-pig ileum.

Authors:  M Nakamoto; C Tanaka; K Taniyama
Journal:  Br J Pharmacol       Date:  1987-03       Impact factor: 8.739

8.  Nanoliposomal short-chain ceramide inhibits agonist-dependent translocation of neurotensin receptor 1 to structured membrane microdomains in breast cancer cells.

Authors:  Yasser Heakal; Mark Kester
Journal:  Mol Cancer Res       Date:  2009-05-12       Impact factor: 5.852
  8 in total

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