Literature DB >> 477724

Sulpiride: a weak antagonist of norepinephrine and 5-hydroxytryptamine.

J D Kohli, L D Cripe.   

Abstract

Antagonism of norepinephrine (NE) and 5-hydroxytryptamine (5-HT) by sulpiride was studied in vitro on rabbit aortic strips. Concentrations of sulpiride ranging from 3 X 10(-5) to 3 X 10(-3) M caused a progressive shift of the dose response curves of both NE and 5-HT to the right without inhibiting the responses to KCl. pA2 values of sulpiride calculated from Schild plots against NE and 5-HT were 4.6 and 4.4, respectively. Thus, sulpiride, which has been previously shown to be the most potent antagonist of the dopamine vascular receptors, is a very weak alpha-adrenergic or 5-HT antagonist.

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Year:  1979        PMID： 477724     DOI： 10.1016/0014-2999(79)90185-7

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  9 in total

1.  Vasodilator response to dopamine in the ferret pulmonary circulation.

Authors:  P Gorman
Journal:  Br J Pharmacol       Date:  1988-05       Impact factor: 8.739

2.  Dissociation of renal vasodilator and natriuretic effects of dopamine during sulpiride infusion in normal man.

Authors:  A J Smit; S Meijer; H Wesseling; A J Donker; W D Reitsma
Journal:  Eur J Clin Pharmacol       Date:  1990       Impact factor: 2.953

3.  Enhancement of noradrenaline release from rat cerebral cortex by neuroleptic drugs.

Authors:  G Gross; H J Schümann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1980       Impact factor: 3.000

4.  Inhibitory dopamine receptors on sympathetic neurons innervating the cardiovascular system of the pithed rat. Characterization and role in relation to presynaptic alpha 2-adrenoceptors.

Authors:  B Wilffert; G Smit; A de Jonge; M J Thoolen; P B Timmermans; P A van Zwieten
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-06       Impact factor: 3.000

5.  The role of presynaptic receptors in the cardiovascular actions of N,N-di-n-propyldopamine in the cat and dog.

Authors:  R Massingham; M L Dubocovich; S Z Langer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1980-10       Impact factor: 3.000

6.  The inhibition by dopamine of cholinergic transmission in the isolated guinea-pig ileum. Mediation through alpha-adrenoceptors.

Authors:  R Görich; T R Weihrauch; H Kilbinger
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-03       Impact factor: 3.000

7.  Dopaminergic modulation of hippocampal noradrenaline release. Evidence for alpha 2-antagonistic effects of some dopamine receptor agonists and antagonists.

Authors:  R Jackisch; S Moll; T J Feuerstein; G Hertting
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-08       Impact factor: 3.000

8.  (+)-sulpiride antagonises the renal effects of gamma-L-glutamyl-L-dopa in man.

Authors:  T M MacDonald; R F Jeffrey; S Freestone; M R Lee
Journal:  Br J Clin Pharmacol       Date:  1988-02       Impact factor: 4.335

9.  Flexible versus Fixed Spatial Self-Ordered Response Sequencing: Effects of Inactivation and Neurochemical Modulation of Ventrolateral Prefrontal Cortex.

Authors:  S F A Axelsson; N K Horst; Naotaka Horiguchi; A C Roberts; T W Robbins
Journal:  J Neurosci       Date:  2021-07-14       Impact factor: 6.167
  9 in total

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