Literature DB >> 4774398

Lysine metabolism in mammals.

F C Fellows, M H Lewis.   

Abstract

The enzymes involved in the initial degradative steps of lysine metabolism, lysine-2-oxoglutarate reductase and saccharopine dehydrogenase, were studied and their activities in different mammals compared. Values obtained in human, rat, pig, dog, cat, ox and sheep liver indicated that in vitro, appreciable degradation of lysine to saccharopine (4-6nmol/min per mg of protein) occurred. The specific activity of saccharopine dehydrogenase in most species studied was higher than that of lysine-oxoglutarate reductase. The rate of production of glutamate from saccharopine in each animal species was investigated and related to the rate of production of alpha-aminoadipate. The rate of formation of lysine from saccharopine, catalysed by saccharopine oxidoreductase, was examined and correlated with the dietary intake of lysine in each species studied.

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Year:  1973        PMID： 4774398      PMCID： PMC1165958          DOI： 10.1042/bj1360329

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  12 in total

1.  The amino acid requirements of man. XV. The valine requirement; summary and final observations.

Authors:  W C ROSE; R L WIXOM; H B LOCKHART; G F LAMBERT
Journal:  J Biol Chem       Date:  1955-12       Impact factor: 5.157

2.  epsilon-lysine acylase.

Authors:  W K PAIK; L BLOCH-FRANKENTHAL; S M BIRNBAUM; M WINITZ; J P GREENSTEIN
Journal:  Arch Biochem Biophys       Date:  1957-07       Impact factor: 4.013

3.  The lysine requirements of the adult rat.

Authors:  A Neuberger; T A Webster
Journal:  Biochem J       Date:  1945       Impact factor: 3.857

4.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

5.  Saccharopine cleavage by a dehydrogenase of human liver.

Authors:  J Hutzler; J Dancis
Journal:  Biochim Biophys Acta       Date:  1970-05-13

6.  The conversion of L-lysine to saccharopine and alpha-aminoadipate in mouse.

Authors:  K Higashino; M Fujioka; Y Yamamura
Journal:  Arch Biochem Biophys       Date:  1971-02       Impact factor: 4.013

7.  The metabolism of D- and L-lysine in the intact rat, perfused liver and liver mitochondria.

Authors:  J Grove; L M Henderson
Journal:  Biochim Biophys Acta       Date:  1968-08-06

8.  Saccharopinuria: a new inborn error of lysine metabolism.

Authors:  N A Carson; B G Scally; D W Neill; L J Carré
Journal:  Nature       Date:  1968-05-18       Impact factor: 49.962

9.  Saccharopine, a product of lysine breakdown by mammalian liver.

Authors:  K Higashino; K Tsukada; I Lieberman
Journal:  Biochem Biophys Res Commun       Date:  1965-07-26       Impact factor: 3.575

10.  Biosynthesis and degradation of saccharopine, an intermediate of lysine metabolism.

Authors:  F C Fellows
Journal:  Biochem J       Date:  1973-10       Impact factor: 3.857
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  17 in total

1.  Mutants of Saccharomycopsis lipolytica defective in lysine catabolism.

Authors:  C Gaillardin; P Fournier; G Sylvestre; H Heslot
Journal:  J Bacteriol       Date:  1976-01       Impact factor: 3.490

2.  α-Ketoadipic Acid and α-Aminoadipic Acid Cause Disturbance of Glutamatergic Neurotransmission and Induction of Oxidative Stress In Vitro in Brain of Adolescent Rats.

Authors:  Janaína Camacho da Silva; Alexandre Umpierrez Amaral; Cristiane Cecatto; Alessandro Wajner; Kálita Dos Santos Godoy; Rafael Teixeira Ribeiro; Aline de Mello Gonçalves; Ângela Zanatta; Mateus Struecker da Rosa; Samanta Oliveira Loureiro; Carmen Regla Vargas; Guilhian Leipnitz; Diogo Onofre Gomes de Souza; Moacir Wajner
Journal:  Neurotox Res       Date:  2017-04-20       Impact factor: 3.911

3.  Alpha-aminoadipic aciduria, a non-deleterious inborn metabolic defect.

Authors:  M H Fischer; T Gerritsen; J M Opitz
Journal:  Humangenetik       Date:  1974

4.  Role of L-lysine-alpha-ketoglutarate aminotransferase in catabolism of lysine as a nitrogen source for Rhodotorula glutinis.

Authors:  J J Kinzel; M K Winston; J K Bhattacharjee
Journal:  J Bacteriol       Date:  1983-07       Impact factor: 3.490

5.  Biosynthesis and degradation of saccharopine, an intermediate of lysine metabolism.

Authors:  F C Fellows
Journal:  Biochem J       Date:  1973-10       Impact factor: 3.857

6.  Lysine degradation through the saccharopine pathway in mammals: involvement of both bifunctional and monofunctional lysine-degrading enzymes in mouse.

Authors:  F Papes; E L Kemper; G Cord-Neto; F Langone; P Arruda
Journal:  Biochem J       Date:  1999-12-01       Impact factor: 3.857

7.  Lysine Catabolism in Barley (Hordeum vulgare L.).

Authors:  B L Møller
Journal:  Plant Physiol       Date:  1976-05       Impact factor: 8.340

Review 8.  Lysine metabolism in mammalian brain: an update on the importance of recent discoveries.

Authors:  André Hallen; Joanne F Jamie; Arthur J L Cooper
Journal:  Amino Acids       Date:  2013-09-17       Impact factor: 3.520

9.  Catabolism of lysine in Penicillium chrysogenum leads to formation of 2-aminoadipic acid, a precursor of penicillin biosynthesis.

Authors:  C Esmahan; E Alvarez; E Montenegro; J F Martin
Journal:  Appl Environ Microbiol       Date:  1994-06       Impact factor: 4.792

10.  Purification and Characterization of the Bifunctional Enzyme Lysine-Ketoglutarate Reductase-Saccharopine Dehydrogenase from Maize.

Authors:  M. Goncalves-Butruille; P. Szajner; E. Torigoi; A. Leite; P. Arruda
Journal:  Plant Physiol       Date:  1996-03       Impact factor: 8.340
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