Literature DB >> 47739

Observations on phagocytosis of urate crystals by polymorphonuclear leucocytes.

K T Rajan.   

Abstract

The sequence of events that may initiate the inflammatory reaction in acute gout has been investigated with specific reference to phagocytosis of urate crystals by polymorphonuclear leucocytes and the results have shown (1) that neutrophil leucocytes avidly ingest microcrystals of sodium monourate, (2) that this causes the rapid degranulation and disintegration of the leucocytes, (3) that fresh leucocytes ingest the debris and crystals liberated by the dead cells, and in their turn degranulate and die, thus possibly establishing a vicious circle in the system.

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Year:  1975        PMID： 47739      PMCID： PMC1006345          DOI： 10.1136/ard.34.1.54

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  10 in total

1.  Lysosomes and vacuolation of the liver cell.

Authors:  D B BREWER; D HEATH
Journal:  Nature       Date:  1963-06-08       Impact factor: 49.962

2.  ELECTRON MICROSCOPY OF PHAGOCYTOSIS OF STAPHYLOCOCCI.

Authors:  D B BREWER
Journal:  J Pathol Bacteriol       Date:  1963-10

3.  Metabolic basis of phagocytic activity.

Authors:  M L KARNOVSKY
Journal:  Physiol Rev       Date:  1962-01       Impact factor: 37.312

4.  The inflammatory reaction to microcrystalline sodium urate.

Authors:  D J McCarty
Journal:  Arthritis Rheum       Date:  1965-10

5.  Lysosomes and gout.

Authors:  K T Rajan
Journal:  Nature       Date:  1966-05-28       Impact factor: 49.962

6.  Studies of phagocytosis of group A streptococci by polymorphonuclear leucocytes in vitro.

Authors:  J G HIRSCH; A B CHURCH
Journal:  J Exp Med       Date:  1960-03-01       Impact factor: 14.307

7.  ELECTRON MICROSCOPE STUDIES ON THE DEGRANULATION OF RABBIT PERITONEAL LEUKOCYTES DURING PHAGOCYTOSIS.

Authors:  D ZUCKER-FRANKLIN; J G HIRSCH
Journal:  J Exp Med       Date:  1964-10-01       Impact factor: 14.307

8.  Origin of granules in polymorphonuclear leukocytes. Two types derived from opposite faces of the Golgi complex in developing granulocytes.

Authors:  D F Bainton; M G Farquhar
Journal:  J Cell Biol       Date:  1966-02       Impact factor: 10.539

9.  The isolation and properties of the specific cytoplasmic granules of rabbit polymorphonuclear leucocytes.

Authors:  Z A COHN; J G HIRSCH
Journal:  J Exp Med       Date:  1960-12-01       Impact factor: 14.307

10.  Cinemicrophotographic observations on granule lysis in polymorphonuclear leucocytes during phagocytosis.

Authors:  J G HIRSCH
Journal:  J Exp Med       Date:  1962-12-01       Impact factor: 14.307
  10 in total
  3 in total

1.  Acute hyperuricemic nephropathy in rats. An electron microscopic study.

Authors:  J Waisman; L M Mwasi; R Bluestone; J R Klinenberg
Journal:  Am J Pathol       Date:  1975-11       Impact factor: 4.307

2.  The relationship between genetics and environment in the pathogenesis of rheumatic diseases.

Authors:  A Calin
Journal:  West J Med       Date:  1979-09

3.  Animal model of acute gout reproduces the inflammatory and ultrasonographic joint changes of human gout.

Authors:  Carlos Pineda; Arturo J Fuentes-Gómez; Cristina Hernández-Díaz; Yessica Zamudio-Cuevas; Javier Fernández-Torres; Ambar López-Macay; Ismael Alba-Sánchez; Javier Camacho-Galindo; Lucio Ventura; Luis E Gómez-Quiróz; María Concepción Gutiérrez-Ruíz; Francisco García-Vázquez; Anthony M Reginato; Marwin Gutiérrez; Alberto López-Reyes
Journal:  Arthritis Res Ther       Date:  2015-02-26       Impact factor: 5.156
  3 in total

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