Literature DB >> 4772278

Purification and properties of an enzyme duet, phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthetase, involved in the biosynthesis of purine nucleotides de novo.

C A Patey, G Shaw.   

Abstract

Purification and some properties of an adjacent pair of enzymes in the biosynthetic pathway to AMP, phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) and phosphoribosylaminoimidazolesuccinocarboxamide synthetase (EC 6.3.2.6), are described. The enzymes form a duet, which may be regarded as a single molecule with a dual function, or as two very similar substances.

Entities:  

Mesh：

Substances：

Year:  1973        PMID： 4772278      PMCID： PMC1165858          DOI： 10.1042/bj1350543

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  6 in total

1.  Biosynthesis of the purines. XVIII. 5-Amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase and inosinicase.

Authors:  J G FLAKS; M J ERWIN; J M BUCHANAN
Journal:  J Biol Chem       Date:  1957-12       Impact factor: 5.157

2.  Glutamine phosphoribosylpyrophosphate amidotransferase. Purification, substructure, amino acid composition, and absorption spectra.

Authors:  P B Rowe; J B Wyngaarden
Journal:  J Biol Chem       Date:  1968-12-25       Impact factor: 5.157

Review 3.  Strategy and tactics in protein chemistry.

Authors:  B S Hartley
Journal:  Biochem J       Date:  1970-10       Impact factor: 3.857

4.  Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels.

Authors:  A L Shapiro; E Viñuela; J V Maizel
Journal:  Biochem Biophys Res Commun       Date:  1967-09-07       Impact factor: 3.575

5.  Biosynthesis of the purines. XXIX. Purification and properties of formylglycinamide ribonucleotide amidotransferase from chicken liver.

Authors:  K Mizobuchi; J M Buchanan
Journal:  J Biol Chem       Date:  1968-09-25       Impact factor: 5.157

6.  Aminoimidazole ribonucleotide carboxylase. Partial purification and properties.

Authors:  F Ahmad; P Missimer; A G Moat
Journal:  Can J Biochem       Date:  1965-10
  6 in total
  7 in total

1.  Molecular genetic analysis of Saccharomyces cerevisiae C1-tetrahydrofolate synthase mutants reveals a noncatalytic function of the ADE3 gene product and an additional folate-dependent enzyme.

Authors:  C K Barlowe; D R Appling
Journal:  Mol Cell Biol       Date:  1990-11       Impact factor: 4.272

2.  Nucleotide sequence analysis of the purEK operon encoding 5'-phosphoribosyl-5-aminoimidazole carboxylase of Escherichia coli K-12.

Authors:  A A Tiedeman; J Keyhani; J Kamholz; H A Daum; J S Gots; J M Smith
Journal:  J Bacteriol       Date:  1989-01       Impact factor: 3.490

3.  Cloning and sequencing of a human cDNA coding for a multifunctional polypeptide of the purine pathway by complementation of the ade2-101 mutant in Saccharomyces cerevisiae.

Authors:  M Minet; F Lacroute
Journal:  Curr Genet       Date:  1990-11       Impact factor: 3.886

4.  Cloning of a chicken liver cDNA encoding 5-aminoimidazole ribonucleotide carboxylase and 5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase by functional complementation of Escherichia coli pur mutants.

Authors:  Z D Chen; J E Dixon; H Zalkin
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

5.  DNA sequence of the purC gene encoding 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide synthetase and organization of the dapA-purC region of Escherichia coli K-12.

Authors:  A A Tiedeman; D J DeMarini; J Parker; J M Smith
Journal:  J Bacteriol       Date:  1990-10       Impact factor: 3.490

6.  Cloning of three human multifunctional de novo purine biosynthetic genes by functional complementation of yeast mutations.

Authors:  D Schild; A J Brake; M C Kiefer; D Young; P J Barr
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

7.  Purification of adenylosuccinate lyase from rat skeletal muscle by a novel affinity column. Stabilization of the enzyme, and effects of anions and fluoro analogues of the substrate.

Authors:  P J Casey; J M Lowenstein
Journal:  Biochem J       Date:  1987-09-01       Impact factor: 3.857
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.