| Literature DB >> 475889 |
I Emerit, J Emerit, A Levy, M Keck.
Abstract
The incidence of chromosome breakage was found to be elevated in 42 patients with Crohn's disease. This phenomenon was much more striking in cultures set up with TCM 199 than in cultures set up with RPMI 1629 rich in L-cysteine. The drug D-penicillamine, a close analog of L-cysteine, gave an apparent therapeutic response in several patients and reduced the chromosome breakage frequency in the lymphocytes of these patients in vitro and in vivo.Entities:
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Year: 1979 PMID： 475889 DOI： 10.1007/bf00295589
Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132