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Literature DB >> 4755182

Itch: role of prostaglandins.

Abstract

Prostaglandin E(1) lowers the threshold of human skin to histamine-evoked itching. Though histamine and other mediators may produce itching by a direct action, itching in inflamed skin can also be explained by a pharmacological synergism in which low concentrations of prostaglandins, which do not themselves cause itching, potentiate itching due to histamine and possibly other agents. Alteration of threshold responses of components of inflammation to other mediators may be an important general role of prostaglandins.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 1973 PMID： 4755182 PMCID： PMC1586899 DOI： 10.1136/bmj.3.5881.608

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

7 in total

1. Prostaglandin E1: effect on human cutaneous vasculature and skin histamine.

Authors: J Sondergaard; M W Greaves
Journal: Br J Dermatol Date: 1971-05 Impact factor: 9.302

2. Urticaria pigmentosa and factitious urticaria. Direct evidence for release of histamine and other smooth muscle-contracting agents in dermographic skin.

Authors: M W Greaves; J Sondergaard
Journal: Arch Dermatol Date: 1970-04

3. Prostaglandins in human burn blister fluid.

Authors: G Arturson; M Hamberg; C E Jonsson
Journal: Acta Physiol Scand Date: 1973-02

4. Prostaglandin on cutaneous vasculature.

Authors: L M Solomon; L Juhlin; M B Kirschenbaum
Journal: J Invest Dermatol Date: 1968-10 Impact factor: 8.551

5. Pharmacologic agents released in ultraviolet inflammation studied by continuous skin pefusion.

Authors: M W Greaves; J Sondergaard
Journal: J Invest Dermatol Date: 1970-05 Impact factor: 8.551

6. Prostaglandins, aspirin-like drugs and analgesia.

Authors: S H Ferreira
Journal: Nat New Biol Date: 1972-12-13

7. Recovery of prostaglandins in human cutaneous inflammation.

Authors: M W Greaves; J Sondergaard; W McDonald-Gibson
Journal: Br Med J Date: 1971-05-01

7 in total

13 in total

Review 4. Acute inflammation. A review.

Authors: G B Ryan; G Majno
Journal: Am J Pathol Date: 1977-01 Impact factor: 4.307

5. Diseases of the skin. The management of pruritus.

Authors: J A Savin
Journal: Br Med J Date: 1973-12-29

6. Inflammatory effects of prostaglandin D2 in rat and human skin.

Authors: R J Flower; E A Harvey; W P Kingston
Journal: Br J Pharmacol Date: 1976-02 Impact factor: 8.739

Review 7. The role of interleukins and nitric oxide in the mediation of inflammatory pain and its control by peripheral analgesics.

Authors: S H Ferreira
Journal: Drugs Date: 1993 Impact factor: 9.546

Itch: role of prostaglandins.

1. Prostaglandin E1: effect on human cutaneous vasculature and skin histamine.

2. Urticaria pigmentosa and factitious urticaria. Direct evidence for release of histamine and other smooth muscle-contracting agents in dermographic skin.

3. Prostaglandins in human burn blister fluid.

4. Prostaglandin on cutaneous vasculature.

5. Pharmacologic agents released in ultraviolet inflammation studied by continuous skin pefusion.

6. Prostaglandins, aspirin-like drugs and analgesia.

7. Recovery of prostaglandins in human cutaneous inflammation.

1. Pruritus in the elderly: clinical approaches to the improvement of quality of life.

2. Effect of aspirin on pruritus.

3. The efficacy of histamine antagonists as antipruritics in experimentally induced pruritus.

Review 4. Acute inflammation. A review.

5. Diseases of the skin. The management of pruritus.

6. Inflammatory effects of prostaglandin D2 in rat and human skin.

Review 7. The role of interleukins and nitric oxide in the mediation of inflammatory pain and its control by peripheral analgesics.

Review 8. Peripheral analgesia: mechanism of the analgesic action of aspirin-like drugs and opiate-antagonists.

Review 9. Corneal reepithelialization and anti-inflammatory agents.

10. Sensory responses of human skin to synthetic histamine analogues and histamine.