Literature DB >> 475371

Isolation and properties of metronidazole-resistant mutants of Bacteroides fragilis.

M L Britz, R G Wilkinson.   

Abstract

Metronidazole-resistant mutants of Bacteroides fragilis, isolated after mutagenesis, had diminished ability to take up and metabolize the drug. All the metronidazole-resistant strains had depressed levels of pyruvate dehydrogenase compared with parent cultures. Their end products of glucose metabolism also differed from normal B. fragilis products and were consistent with deficiencies in pyruvate dehydrogenase activity.

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Year:  1979        PMID： 475371      PMCID： PMC352781          DOI： 10.1128/AAC.16.1.19

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Antimicrobial activity of metronidazole in anaerobic bacteria.

Authors:  F P Tally; B R Goldin; N Sullivan; J Johnston; S L Gorbach
Journal:  Antimicrob Agents Chemother       Date:  1978-03       Impact factor: 5.191

2.  Chloramphenicol acetyltransferase of Bacteroides fragilis.

Authors:  M L Britz; R G Wilkinson
Journal:  Antimicrob Agents Chemother       Date:  1978-07       Impact factor: 5.191

3.  Anaerobic bacteriology. Isolation and identification of Bacteroides and Fusobacterium from human sources.

Authors:  G Cadogan-Cowper; R G Wilkinson
Journal:  Aust J Exp Biol Med Sci       Date:  1974-12

4.  The mode of action of metronidazole in Trichomonas vaginalis and other micro-organisms.

Authors:  R M Ings; J A McFadzean; W E Ormerod
Journal:  Biochem Pharmacol       Date:  1974-05-01       Impact factor: 5.858

5.  Letter: "High-dose" metronidazole: a preliminary pharmacological study prior to its investigational use in clinical radiotherapy trials.

Authors:  R C Urtasun; J Sturmwind; H Rabin; P R Band; J D Chapman
Journal:  Br J Radiol       Date:  1974-05       Impact factor: 3.039

6.  Hydrogenosome, a cytoplasmic organelle of the anaerobic flagellate Tritrichomonas foetus, and its role in pyruvate metabolism.

Authors:  D G Lindmark; M Müller
Journal:  J Biol Chem       Date:  1973-11-25       Impact factor: 5.157

7.  Purification and properties of beta-lactamase from Bacteroides fragilis.

Authors:  M L Britz; R G Wilkinson
Journal:  Antimicrob Agents Chemother       Date:  1978-03       Impact factor: 5.191

8.  NAD- and NADP-dependent 7alpha-hydroxysteroid dehydrogenases from bacteroides fragilis.

Authors:  I A Macdonald; C N Williams; D E Mahony; W M Christie
Journal:  Biochim Biophys Acta       Date:  1975-03-28

9.  Unique bactericidal action of metronidazole against Bacteroides fragilis and Clostridium perfringens.

Authors:  E D Ralph; W M Kirby
Journal:  Antimicrob Agents Chemother       Date:  1975-10       Impact factor: 5.191

10.  Prophylactic oral antimicrobial agents in elective colonic surgery. A controlled trial.

Authors:  J Goldring; W McNaught; A Scott; G Gillespie
Journal:  Lancet       Date:  1975-11-22       Impact factor: 79.321
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  14 in total

1.  Bacteremia caused by a metronidazole-resistant Prevotella sp. strain.

Authors:  Francine Mory; Jean-Philippe Carlier; Corentine Alauzet; Maxime Thouvenin; Hélène Schuhmacher; Alain Lozniewski
Journal:  J Clin Microbiol       Date:  2005-10       Impact factor: 5.948

2.  Influence of Metronidazole, CO, CO(2), and Methanogens on the Fermentative Metabolism of the Anaerobic Fungus Neocallimastix sp. Strain L2.

Authors:  F D Marvin-Sikkema; E Rees; M N Kraak; J C Gottschal; R A Prins
Journal:  Appl Environ Microbiol       Date:  1993-08       Impact factor: 4.792

Review 3.  Pharmacokinetics and pharmacodynamics of the nitroimidazole antimicrobials.

Authors:  K C Lamp; C D Freeman; N E Klutman; M K Lacy
Journal:  Clin Pharmacokinet       Date:  1999-05       Impact factor: 6.447

4.  Metabolic activities of metronidazole-sensitive and -resistant strains of Helicobacter pylori: repression of pyruvate oxidoreductase and expression of isocitrate lyase activity correlate with resistance.

Authors:  P S Hoffman; A Goodwin; J Johnsen; K Magee; S J Veldhuyzen van Zanten
Journal:  J Bacteriol       Date:  1996-08       Impact factor: 3.490

5.  Metronidazole resistance of Trichomonas vaginalis as a cause of treatment failure in trichomoniasis--A case report.

Authors:  J Kulda; M Vojtĕchovská; J Tachezy; P Demes; E Kunzová
Journal:  Br J Vener Dis       Date:  1982-12

6.  Evaluation of broth disk elution methods for susceptibility testing of anaerobic bacteria with the newer beta-lactam antibiotics.

Authors:  J H Jorgensen; J S Redding; A W Howell
Journal:  J Clin Microbiol       Date:  1986-03       Impact factor: 5.948

Review 7.  Mechanisms of selective toxicity of metronidazole and other nitroimidazole drugs.

Authors:  D I Edwards
Journal:  Br J Vener Dis       Date:  1980-10

Review 8.  An Updated Review on the Synthesis and Antibacterial Activity of Molecular Hybrids and Conjugates Bearing Imidazole Moiety.

Authors:  Renzo Rossi; Maurizio Ciofalo
Journal:  Molecules       Date:  2020-11-04       Impact factor: 4.411

9.  Isolation of metronidazole-resistant Bacteroides fragilis carrying the nimA nitroreductase gene from a patient in Washington State.

Authors:  Jeffrey M Schapiro; Rachna Gupta; Eric Stefansson; Ferric C Fang; Ajit P Limaye
Journal:  J Clin Microbiol       Date:  2004-09       Impact factor: 5.948

10.  Overexpression of the rhamnose catabolism regulatory protein, RhaR: a novel mechanism for metronidazole resistance in Bacteroides thetaiotaomicron.

Authors:  Ekta H Patel; Lynthia V Paul; Ana I Casanueva; Sheila Patrick; Valerie R Abratt
Journal:  J Antimicrob Chemother       Date:  2009-06-13       Impact factor: 5.790
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